Quetiapine
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| Pronunciation | /kwɪˈtaɪ.əpiːn/ kwi-TY-ə-peen |
| Trade names | Seroquel, Temprolide, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a698019 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | 100%[2] |
| Protein binding | 83%[3] |
| Metabolism | Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[1] |
| Elimination half-life | 7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[3][4] |
| Excretion | Kidney (73%), faeces (20%)[2][3][4][5] |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C21H25N3O2S |
| Molar mass | 383.5099 g/mol |
| 3D model (JSmol) | |
| Solubility in water | 3.29 mg/mL (20 °C) |
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Quetiapine (better known as Seroquel) is an antipsychotic drug used to treat bipolar disorder and unipolar major depression, though it is used off-label for anxiety problems, Tourette syndrome and autism issues. The side effects of Quetiapine include fatigue, dry mouth and being sleepy. The medication is sometimes used for PTSD.
Quetiapine Media
Quetiapine (Seroquel) 25 mg tablets, next to US one-cent coin for comparison
Seroquel XR 150 mg tablet box
Skeletal formula of norquetiapine
Warawa, E. J.; Migler, B. M.; 1988, U.S. Patent 4,879,288.
References
- ↑ Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.
- ↑ 2.0 2.1 "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Archived from the original on 20 October 2013. Retrieved 11 October 2013.
- ↑ 3.0 3.1 3.2 "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Archived from the original on 20 October 2013. Retrieved 20 October 2013.
- ↑ 4.0 4.1 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
- ↑ "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]". DailyMed. Ascend Laboratories, LLC. October 2013. Archived from the original on 2 December 2013. Retrieved 26 November 2013.
