Atorvastatin
Atorvastatin (brand name Lipitor) is a statin drug.
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It is used for preventing cardiovascular disease and treating abnormal lipid levels[1][2] (to lower cholesterol). In addition heart disease, it is also given to prevent strokes.[2] It may also be prescribed for people with a family history of heart disease, or a long-term health condition such as type 1 or type 2 diabetes or rheumatoid arthritis.[2]
The medication is available as a generic drug.[3][4] In 2021, it was the most commonly prescribed medication in the United States, with more than 116 million prescriptions filled for over 28 million patients.[5] Atorvastatin was first synthesized in 1985 by Dr. Bruce Roth and approved by the FDA in 1996.[6] Patented by Pfizer.
It is on the World Health Organization's List of Essential Medicines.[7]
Atorvastatin Media
Atorvastatin synthesis in commercial production (process) chemistry. The key step of establishing this medication's stereocenters, through initial use of an inexpensive natural product (chiral pool approach).
Atorvastatin synthesis during discovery chemistry. The key step of establishing stereocenters, using of a chiral ester auxiliary approach.
Pack and tablet of atorvastatin (Lipitor) 40mg
Related pages
- Statin: Rosuvastatin
- Cardiovascular system
References
- ↑ "Atorvastatin". Drugs.com. Retrieved May 24, 2021.
- ↑ 2.0 2.1 2.2 "About atorvastatin". nhs.uk. 2022-03-16. Retrieved 2024-05-27.
- ↑ Top 100 Drugs. Elsevier Health Services. 30 March 2014. ISBN 9780702055157. Retrieved May 24, 2021.
- ↑ Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2014-03-30). The Top 100 Drugs e-book: Clinical Pharmacology and Practical Prescribing. Elsevier Health Sciences. ISBN 978-0-7020-5515-7.
- ↑ "The Top 300 of 2021". clincalc.com. Retrieved 2024-05-27.
- ↑ PubChem. "Atorvastatin". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-05-28.
- ↑ Organization, World Health (2021). "World Health Organization model list of essential medicines: 22nd list (2021)". WHO.