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Cancer of unknown primary origin

"Cancer of unknown primary origin" (CUP, "occult cancer") is a term used to describe a cancer that is said to be at the metastatic stage at the time of diagnosis, but a primary tumor cannot be identified. A diagnosis of CUP requires a clinical picture with metastatic disease and one or more biopsy results inconsistent with a primary tumor.[1]

CUP is found in about 3 to 5% of all people diagnosed with invasive cancer,[2] and carries a poor prognosis in most (80 to 85%) of those circumstances. The other 15 to 20% of patients, however, have a relatively long survival with appropriate treatment.[2]

Cancer Of Unknown Primary Origin Media

  • Histopathology of a biopsy of a lymph node with cancer of unknown primary origin, showing high-grade tumor cells which are undifferentiated, that is, the primary tumor cannot be determined by their histologic appearance.

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org.apache.batik.transcoder.SVGAbstractTranscoder.transcode(SVGAbstractTranscoder.java:228) at org.apache.batik.transcoder.image.ImageTranscoder.transcode(ImageTranscoder.java:92) at org.apache.batik.transcoder.XMLAbstractTranscoder.transcode(XMLAbstractTranscoder.java:142) at org.apache.batik.transcoder.SVGAbstractTranscoder.transcode(SVGAbstractTranscoder.java:158) at org.apache.batik.apps.rasterizer.SVGConverter.transcode(SVGConverter.java:1008) at org.apache.batik.apps.rasterizer.SVGConverter.execute(SVGConverter.java:719) at org.apache.batik.apps.rasterizer.Main.execute(Main.java:956) at org.apache.batik.apps.rasterizer.Main.main(Main.java:1009) Caused by: org.apache.batik.bridge.BridgeException: file:/var/www/html/w/images/temp/svg_b1b7d2c94d8c488bb89c131c/CK7_and_CK20_by_body_location.svg:0 The URI "data:image/gif;base64,R0lGODlhTgBgAPcAAAAAADc0Qjo4RTw5Rj88SkA+SkI/TENATUVDUEZEUElGUkpIU0xLVk5MWFBO WVFOWlBQWlNTXVRTXlVVXldVYFhWYFhYYVlYYlpaY1pZZF1aZV5cZl5eaGBeaGFgamRia2RibGVk 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org.apache.batik.bridge.GVTBuilder.buildComposite(GVTBuilder.java:171) at org.apache.batik.bridge.GVTBuilder.buildGraphicsNode(GVTBuilder.java:219) at org.apache.batik.bridge.GVTBuilder.buildComposite(GVTBuilder.java:171) at org.apache.batik.bridge.GVTBuilder.build(GVTBuilder.java:82) at org.apache.batik.transcoder.SVGAbstractTranscoder.transcode(SVGAbstractTranscoder.java:210) ... 7 more ... error (SVGConverter.error.while.rasterizing.file)

    Immunohistochemistry including cytokeratin 7 and cytokeratin 20 can give a clue about possible origins of carcinomas of unknown primary site.

References

  1. ↑ Carcinoma of Unknown Primary Treatment–for health professionals (December 30, 2014)National Cancer Institute. Retrieved 6 July 2015.
  2. ↑ 2.0 2.1 Stella, GM. Cancers of unknown primary origin: current perspectives and future therapeutic strategies.. Journal of Translational Medicine 10 (24 January 2012). p. 12. doi:10.1186/1479-5876-10-12.
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