Clostridioides difficile infection

Clostridioides difficile infection (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection caused by the spore-forming bacterium Clostridioides difficile. Symptoms include watery diarrhea, fever, nausea, and abdominal pain.

It makes up about 20% of cases of antibiotic-associated diarrhea. Problems caused by this infection are pseudomembranous colitis, toxic megacolon, perforation of the colon, and sepsis.

Clostridioides difficile infection is spread by bacterial spores found within feces.

Clostridioides Difficile Infection Media

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  How C. difficile spreads

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  Individual, drumstick-shaped C. difficile bacilli seen through scanning electron microscopy

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  C. difficile colonies on a blood agar plate

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  Micrograph of a colonic pseudomembrane in C. difficile colitis, a type of pseudomembranous colitis, H&E stain

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  Endoscopic image of pseudomembranous colitis, with yellow pseudomembranes seen on the wall of the sigmoid colon

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  Pseudomembranous colitis on computed tomography