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File:Confluent epidermal necrosis - very high mag.jpg

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Summary

Description
English: Very high magnification micrograph of confluent epidermal necrosis. Skin biopsy. H&E stain.

Confluent epidermal necrosis is seen in the context of erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

SJS and TEN are generally considered to be on a spectrum and usually due to medications. EM is histomorphologically indistinguishable from SJS/TEN. It is usually due to an infection.

Histomorphologic features:

  1. A basket weave-type stratum corneum (indicative of the acuity).
  2. Epidermal necrosis.
  3. Separation of the epidermis and dermis.
  4. Minimal inflammation.
  • Low mag.
    Low mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.
Source Own work
Author Nephron

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Epidermal Necrosis

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current22:14, 4 October 20114,272 × 2,848 (3.08 MB)Nephron{{Information |Description ={{en|1=Very high magnification micrograph of '''confluent epidermal necrosis'''. Skin biopsy. H&E stain. Confluent epidermal necrosis i

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