Klinefelter syndrome
Klinefelter syndrome, 47, XXY, or XXY syndrome is a genetic disorder where people have an extra number of X chromosomes.[1] People who have Klinefelter's Syndrome are often called "XXY Males", or "47, XXY Males".[2]
Effects
Males who have this condition are almost always infertile. This means that they cannot father babies.[3]
In other organisms
Any male mammal can have Klinefelter's Syndrome. The mouse is one example.[4] Tortoiseshell or calico markings on male cats are an indicator of Klinefelter's syndrome. These cats are considered to be the model organism for Klinefelter syndrome, because the gene for a cat's orange/black coat markings is found on the X chromosome. [5]
Klinefelter Syndrome Media
Birth of a cell with karyotype XXY due to a nondisjunction event of one X chromosome from a Y chromosome during meiosis I in the male
Birth of a cell with karyotype XXY due to a nondisjunction event of one X chromosome during meiosis II in the female
References
- ↑ Kumar, Vinay. Robbins and Cotran pathologic basis of disease (2005). Philadelphia: Elsevier/Saunders. ISBN 978-0-7216-0187-8.
- ↑ Bock, Robert. Understanding Klinefelter Syndrome: A Guide for XXY Males and their Families. NIH Pub. No. 93-3202 (1993)Office of Research Reporting, NICHD. Retrieved 2007-04-07.
- ↑ Denschlag, Dominik, MD. Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review. Fertility and Sterility 82 (4) (October 2004). p. 775–779. doi:10.1016/j.fertnstert.2003.09.085.
- ↑ Russell, Liane Brauch. Genetics of Mammalian Sex Chromosomes MOUSE STUDIES THROW LIGHT ON THE FUNCTIONS AND ON THE OCCASIONALLY ABERRANT BEHAVIOR OF SEX CHROMOSOMES. Science 133 (3467) (9 June 1961). p. 1795–1803. doi:10.1126/science.133.3467.1795.
- ↑ An animal model for the XXY Klinefelter's syndrome in man: Tortoiseshell and calico male cats. American Journal of Veterinary Research 36 (9) (1975). p. 1275–1280.
Other websites
- Klinefelter Syndrome at the Open Directory Project. dmoz.org. Retrieved 27 July 2010.