Lewy body

Lewy body is a substance that stains eosin, and commonly found in Parkinson’s disease. The main disease associated with the presence of Lewy bodies is Parkinson's disease. Lewy bodies are also present in neurons in dementia with Lewy bodies and the Lewy body variant of Alzheimer's disease, as well as Hallervorden-Spatz syndrome.

Lewy Body Media

Photomicrograph of a Lewy body (indicated by the arrowhead) in a neuron of the substantia nigra from a person with Parkinson's disease. The brown material in the cytoplasm is neuromelanin. Hematoxylin and eosin stain; scale bar=20 microns [0.02mm].
Photomicrograph of alpha-synuclein (black) in a Lewy body (upper left) and Lewy neurite (arrow) near an Abeta plaque (brown) in the brain of an elderly person who had died with dementia. Lewy pathology is sometimes present along with the plaques and tangles that are characteristic of Alzheimer's disease. Scale bar=20 microns [0.02mm].
Photomicrograph of the dorsal motor nucleus of the vagus nerve (DmX) in a transverse section through the upper medulla that is affected by the abnormal deposition of alpha synuclein in Lewy bodies and Lewy neurites (righthand panel)
Lewy neurites (thread-like structures) and Lewy bodies in a case of Lewy body dementia. Stain: immunohistochemical stain (brown) for alpha-synuclein.