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The story is about a girl called "Little Iodine". She first appeared in an earlier comic strip by Hatlo, called They'll Do It Every Time. She was the daughter of the strip's main character, Henry Tremblechin. She constantly annoyed her father with pranks and practical jokes. The character of Iodine became very popular, so Hatlo promoted the character into her own strip in 1943.
A movie based on the comic strip was released in 1946. It was by Comet Productions. The 56-minute movie stars Jo Ann Marlowe as Little Iodine, Hobart Cavanaugh as her father Henry, and Irene Ryan as her mother Cora.
In the movie, Iodine thinks that her mother is having an affair with Professor Simkins (played by Leon Belasco). She tries one antic after another to break up the couple. Her efforts backfire when they cause conflict between her father and his employer, Mr. Bigdome (Emory Parnell).
The movie was planned to be released earlier than October 20, 1946 (its actual distribution date), but that date was delayed due to an epidemic of polio that prevented children across the United States from attending movies. The movie is believed to be lost.