Madame Web

Madame Web (Cassandra Webb) is a fictional character appearing in American comic books published by Marvel Comics. Madame Web first appeared in The Amazing Spider-Man #210, published November 1980, and was created by the late writer Denny O'Neil and artist John Romita, Jr. She is usually depicted as a supporting character in the Spider-Man comic book series. She is depicted as an elder woman with myasthenia gravis and thus was connected to a life support system that looked like a spider web. Due to her age and medical condition Madame Web never actively fought any villains.

Dakota Johnson will play Madame Web in an upcoming solo film set in Sony's Spider-Man Universe.