Merkel-cell carcinoma

Merkel-cell carcinoma (MCC) is a rare and aggressive skin cancer happening in about 3 per 1,000,000 population.^[1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin.^[2]

Reasons why the cancer would form is because of Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation.^[3]^[4]

Merkel-cell carcinoma usually shows up on the head, neck, perianal and eyelid.^[5] It is more common in elderly people.

Merkel-cell Carcinoma Media

Small spot on the left arm is Merkel-cell cancer.
Merkel-cell carcinoma. Gross pathology specimen.
Merkel-cell carcinoma (arrow) infiltrating skin tissue, stained brown for Merkel cell polyomavirus large T protein
Photomicrographs of a typical Merkel-cell carcinoma at a 4x, b 40x, and c–d 100x objectives. Hematoxylin and eosin staining demonstrates small, undifferentiated cells with high N/C ratio and scanty cytoplasm.

References

↑ "Merkel-cell carcinima". Dynamed. Archived from the original on 2020-02-19. Retrieved 2019-11-11.
↑ Dermatology. Bolognia, Jean., Jorizzo, Joseph L., Rapini, Ronald P. (2nd ed.). St. Louis, MO: Mosby/Elsevier. 2008. ISBN 978-1-4160-2999-1. OCLC 212399895.{{cite book}}: CS1 maint: others (link)
↑ Kervarrec, Thibault; Samimi, Mahtab; Guyétant, Serge; Sarma, Bhavishya; Chéret, Jérémy; Blanchard, Emmanuelle; Berthon, Patricia; Schrama, David; Houben, Roland; Touzé, Antoine (10 June 2019). "Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review". Frontiers in Oncology. 9: 451. doi:10.3389/fonc.2019.00451. PMC 6579919. PMID 31245285.
↑ Rotondo, John Charles; Bononi, Ilaria; Puozzo, Andrea; Govoni, Marcello; Foschi, Valentina; Lanza, Giovanni; Gafà, Roberta; Gaboriaud, Pauline; Touzé, Françoise Antoine; Selvatici, Rita; Martini, Fernanda; Tognon, Mauro (15 July 2017). "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF". Clinical Cancer Research. 23 (14): 3929–3934. doi:10.1158/1078-0432.CCR-16-2899. PMID 28174236.
↑ Patterson, James W. (James Willis), 1946- (2014-12-07). Weedon's skin pathology. Hosler, Gregory A. (Fourth ed.). [Edinburgh?]. ISBN 978-0-7020-6200-1. OCLC 900724639.{{cite book}}: CS1 maint: multiple names: authors list (link)

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[:0-1] "Merkel-cell carcinima". Dynamed. Archived from the original on 2020-02-19. Retrieved 2019-11-11.

[2] Dermatology. Bolognia, Jean., Jorizzo, Joseph L., Rapini, Ronald P. (2nd ed.). St. Louis, MO: Mosby/Elsevier. 2008. ISBN 978-1-4160-2999-1. OCLC 212399895.{{cite book}}: CS1 maint: others (link)

[Kervarrec_451-3] Kervarrec, Thibault; Samimi, Mahtab; Guyétant, Serge; Sarma, Bhavishya; Chéret, Jérémy; Blanchard, Emmanuelle; Berthon, Patricia; Schrama, David; Houben, Roland; Touzé, Antoine (10 June 2019). "Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review". Frontiers in Oncology. 9: 451. doi:10.3389/fonc.2019.00451. PMC 6579919. PMID 31245285.

[pmid28174236-4] Rotondo, John Charles; Bononi, Ilaria; Puozzo, Andrea; Govoni, Marcello; Foschi, Valentina; Lanza, Giovanni; Gafà, Roberta; Gaboriaud, Pauline; Touzé, Françoise Antoine; Selvatici, Rita; Martini, Fernanda; Tognon, Mauro (15 July 2017). "Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF". Clinical Cancer Research. 23 (14): 3929–3934. doi:10.1158/1078-0432.CCR-16-2899. PMID 28174236.

[:1-5] Patterson, James W. (James Willis), 1946- (2014-12-07). Weedon's skin pathology. Hosler, Gregory A. (Fourth ed.). [Edinburgh?]. ISBN 978-0-7020-6200-1. OCLC 900724639.{{cite book}}: CS1 maint: multiple names: authors list (link)

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