Merkel-cell carcinoma
Merkel-cell carcinoma (MCC) is a rare and aggressive skin cancer happening in about 3 per 1,000,000 population.[1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin.[2]
Reasons why the cancer would form is because of Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation.[3][4]
Merkel-cell carcinoma usually shows up on the head, neck, perianal and eyelid.[5] It is more common in elderly people.
Merkel-cell Carcinoma Media
Small spot on the left arm is Merkel-cell cancer.
Merkel-cell carcinoma. Gross pathology specimen.
Merkel-cell carcinoma (arrow) infiltrating skin tissue, stained brown for Merkel cell polyomavirus large T protein
Photomicrographs of a typical Merkel-cell carcinoma at a 4x, b 40x, and c–d 100x objectives. Hematoxylin and eosin staining demonstrates small, undifferentiated cells with high N/C ratio and scanty cytoplasm.
References
- ↑ Merkel-cell carcinima. Dynamed. Retrieved 2019-11-11.
- ↑ Dermatology (2008). St. Louis, MO: Mosby/Elsevier. ISBN 978-1-4160-2999-1. OCLC 212399895.
- ↑ Kervarrec, Thibault. Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review. Frontiers in Oncology 9 (10 June 2019). p. 451. doi:10.3389/fonc.2019.00451.
- ↑ Rotondo, John Charles. Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF. Clinical Cancer Research 23 (14) (15 July 2017). p. 3929–3934. doi:10.1158/1078-0432.CCR-16-2899.
- ↑ Patterson, James W. (James Willis), 1946-. Weedon's skin pathology (2014-12-07). [Edinburgh?]. ISBN 978-0-7020-6200-1. OCLC 900724639.
