Multiple myeloma

Multiple myeloma is a type of cancer involving the plasma cells. Some symptoms of the multiple myeloma are bone pain, kidney failure, recurring infections and anemia. It is treated with chemotherapy. A commonly used chemotherapy regimen is the vincristine, adriamycin, and dexamethasone. thalidomides, velcades, melphalans, prednisones and interferons have also been used.

Multiple Myeloma Media

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Illustration showing the most common site of bone lesions in vertebrae
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Plasmablast, Wright stain, in a case of multiple myeloma of plasmablastic type.
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Serum protein electropherogram showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma
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Deaths from lymphomas and multiple myeloma per million persons in 2012*
0–13 14–18 19–22 23–28 29–34 35–42 43–57 58–88 89–121 122–184
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Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, H&E stain
Micrograph of a plasmacytoma. H&E stain.*The micrograph shows abundant (malignant) plasma cells with the occasional Mott cell, a plasma cell with an intracytoplasmic
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Micrograph showing myeloma cast nephropathy in a kidney biopsy: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), PAS stain.
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Atypical plasma cell infiltrate with both Russell (cytoplasmic) and Dutcher (nuclear) bodies (H&E, 50x)