Multiple myeloma
Multiple myeloma is a type of cancer involving the plasma cells. Some symptoms of the multiple myeloma are bone pain, renal failure, recurring infections and anemia. It is treated with chemotherapy. A commonly used chemotherapy regimen is the Vincristine, Adriamycin, and Dexamethasone. Thalidomides, velcades, melphalans, prednisones and interferons have also been used.
Multiple Myeloma Media
Illustration showing the most common site of bone lesions in vertebrae
Plasmablast, Wright stain, in a case of multiple myeloma of plasmablastic type.
Serum protein electropherogram showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma
Deaths from lymphomas and multiple myeloma per million persons in 2012*0–13 14–18 19–22 23–28 29–34 35–42 43–57 58–88 89–121 122–184
Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, H&E stain
Micrograph of a plasmacytoma. H&E stain.*The micrograph shows abundant (malignant) plasma cells with the occasional Mott cell, a plasma cell with an intracytoplasmic
Micrograph showing myeloma cast nephropathy in a kidney biopsy: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), PAS stain.
Atypical plasma cell infiltrate with both Russell (cytoplasmic) and Dutcher (nuclear) bodies (H&E, 50x)
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