Secretin
Secretin is a peptide hormone that regulates water balance throughout the body. It is produced in secretory glands of the duodenum.[1] In humans, the secretin peptide is encoded by the SCT gene, which sits on chromosome 11.[2]
In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.[3][4]
Secretin was the first hormone to be identified.[5] The crucial experiments were done at University College London in 1902. The term 'hormone' was invented in 1905.[6]
References
- ↑ Secretin. Clinics in Gastroenterology 9 (3) (1980). p. 609–32. doi:10.1016/S0300-5089(21)00474-0.
- ↑ Secretin: structure of the precursor and tissue distribution of the mRNA. Proceedings of the National Academy of Sciences of the United States of America 87 (6) (1990). p. 2299–303. doi:10.1073/pnas.87.6.2299.
- ↑ Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Molecular and Cellular Biology 27 (7) (2007). p. 2499–511. doi:10.1128/MCB.01088-06.
- ↑ Secretin as a neurohypophysial factor regulating body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America 106 (37) (2009). p. 15961–6. doi:10.1073/pnas.0903695106.
- ↑ Sekretin - det første hormon (in Danish). Ugeskrift for Laeger 164 (3) (2002). p. 320–5.
- ↑ Hirst, BH. Secretin and the exposition of hormonal control. J Physiol 560 (Pt 2) (2004). p. 339. doi:10.1113/jphysiol.2004.073056.