Sirtuin
Sirtuin or Sir2 proteins are a class of enzymes that are important in cell biology.[1][2][3][4][5]
Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',[6] the gene responsible for cellular regulation in yeast.
Sirtuins influence many cellular processes like ageing, transcription, apoptosis, inflammation and stress resistance,[7] as well as energy efficiency and alertness during low-calorie situations.[8] Sirtuins can also control circadian clocks and mitochondrial biogenesis.
References
- ↑ North, Brian J.. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biology 5 (5) (2004). p. 224. doi:10.1186/gb-2004-5-5-224.
- ↑ Yamamoto, Hiroyasu. Sirtuin functions in health and disease. Mol. Endocrinol. 21 (8) (2007). p. 1745–55. doi:10.1210/me.2007-0079.
- ↑ Du, Jintang. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.. Science 334 (6057) (2011). p. 806–809. doi:10.1126/science.1207861.
- ↑ Jiang, Hong. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.. Nature 496 (7443) (2013). p. 110–113. doi:10.1038/nature12038.
- ↑ Rack J.G.M. et al 2015. Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens. Molecular Cell 59 (2) (2015). p. 309–320. doi:10.1016/j.molcel.2015.06.013.
- ↑ EntrezGene 23410 [1]
- ↑ Preyat, Nicolas. Sirtuin deacylases: a molecular link between metabolism and immunity.. J. Leuk. Biol. 93 (5) (2013). p. 669–680. doi:10.1189/jlb.1112557.
- ↑ Satoh, A.. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.. Journal of Neuroscience 30 (30) (2010). p. 10220–32. doi:10.1523/JNEUROSCI.1385-10.2010.