Streptokinase
Streptokinase (STK) is a thrombolytic medication used to dissolve blood clots (thrombolysis) in human body.[1] Streptokinase is used mainly treat heart attacks (myocardial infarction). There are 2 main types of heart attacks. STEMI and non-STEMI and Streptokinase is only used in STEMI type heart attacks after confirming with an ECG.[2] It is given as an injection into a vein.
Uses
- Heart attack (STEMI Type)
- Pulmonary embolism - Blood clots in arteries of Lungs
- Arterial thromboembolism - Blood clots formed in arteries[3]
Side effects
Common side effects of Streptokinase are;
- Nausea
- Bleeding tendency
- Low blood pressure
- Allergic reactions
It is not recommended to use streptokinase during the lifetime of a person more than once due to the risk of developing allergic reactions.[3]
Discovery
Streptokinase was discovered in 1933 by American microbiologist, William S. Tillett, from a bacteria known as beta-hemolytic streptococci.[1] It is on the World Health Organization's List of Essential Medicines.[4] Streptokinase is no longer used in hospitals to treat heart attacks in many countries including United States. This is because it has been replaced by a medication called Tenecteplase, which has less side effects.[5]
References
- ↑ 1.0 1.1 Sikri, Nikhil. A History of Streptokinase Use in Acute Myocardial Infarction. Texas Heart Institute Journal 34 (3) (2007). p. 318–327.
- ↑ Streptokinase 1,500,000 iu - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Retrieved 2020-09-21.
- ↑ 3.0 3.1 Organization, World Health. WHO model formulary 2008 (in en) (2009)World Health Organization. ISBN 978-92-4-154765-9.
- ↑ Organization, World Health. World Health Organization model list of essential medicines: 21st list 2019 (in en) (2019).
- ↑
Streptokinase Media
Proposed counterion for Asp740 is Lys698 create salt-bridge
Substrate Enzyme Mechanism Movie
Streptokinase Intravenous, Intracoronary Advanced Patient Information (in en). Drugs.com. Retrieved 2020-09-21.
