Bacillus Calmette-Guérin
Bacillus Calmette–Guerin (also called the BCG vaccine) is a vaccine against tuberculosis. The vaccine is based on a bovine strain of the bacterium.
The BCG vaccine was first used medically in 1921.[1] It is on the World Health Organization's List of Essential Medicines.[2] As of 2004, the vaccine is given to about 100 million children per year globally.[3] However, it is not commonly administered in the United States.[4][5][6]
It looks like the vaccine can also be used to treat certain forms of bladder cancer.[7]
Bacillus Calmette-Guérin Media
Micrograph showing granulomatous inflammation of bladder neck tissue due to Bacillus Calmette–Guérin used to treat bladder cancer, H&E stain
An apparatus (4–5 cm length, with 9 short needles) used for BCG vaccination in Japan, shown with ampules of BCG and saline
BCG vaccine scar on the patient's left shoulder
French poster promoting the BCG vaccine
References
- ↑ Santé, World Health Organization = Organisation mondiale de la. BCG vaccines: WHO position paper – February 2018 – Vaccins BCG: Note de synthèse de l'OMS – Février 2018 (in en). Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire 93 (8) (2018-02-23). p. 73–96.
- ↑ The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) (2023). Geneva: World Health Organization.
- ↑ Organization, World Health. BCG Vaccine = Vaccin BCG (in en). Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire 79 (4) (2004). p. 27–38.
- ↑ Summary for ARTG Entry:53569 BCG VACCINE Mycobacterium bovis (Mycobacterium bovis (Bacillus Calmette and Guerin (BCG) strain) (BCG) strain) 1.5mg powder for injection multidose vial with diluent vialTherapeutic Goods Administration (TGA). Retrieved 31 July 2024.
- ↑ The role of BCG vaccine in the prevention and control of tuberculosis in the United States. A joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices. MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports 45 (RR-4) (1996-04-26). p. 1–18.
- ↑ Vaudry, Wendy. "To BCG or not to BCG, that is the question!". The challenge of BCG vaccination: Why can't we get it right?. Paediatrics & Child Health 8 (3) (March 2003). p. 141–144. doi:10.1093/pch/8.3.141.
- ↑ De Jager R, Guinan P, Lamm D, u. a.: Long-term complete remission in bladder carcinoma in situ with intravesical TICE bacillus Calmette Guerin. Overview analysis of six phase II clinical trials. Urology. 1991 Dec;38(6):507-13. PMID 1836081
