Colorectal cancer
Colorectal cancer, also known as colon cancer, rectal cancer, or bowel cancer, is a cancer in the colon or rectum (parts of the large intestine), or in the appendix. Genetic analysis shows that essentially colon and rectal tumours are genetically the same cancer.[1] Symptoms of colorectal cancer typically include rectal bleeding and anemia which are sometimes associated with weight loss and changes in bowel habits (defecation pattern).
Colorectal cancer | |
---|---|
Classification and external resources | |
ICD-10 | C18.-C20./C21. |
ICD-9 | 153.0-154.1 |
ICD-O: | M8140/3 (95% of cases) |
OMIM | 114500 |
DiseasesDB | 2975 |
MedlinePlus | 000262 |
eMedicine | med/413 med/1994 ped/3037 |
It is estimated that worldwide, 1.23 million new cases of colorectal cancer are clinically diagnosed and that it kills 608,000 people per year.[2]
Colorectal Cancer Media
Longitudinally opened freshly resected colon segment showing a cancer and four polyps. Plus a schematic diagram indicating a likely field defect (a region of tissue that precedes and predisposes to the development of cancer) in this colon segment. The diagram indicates sub-clones and sub-sub-clones that were precursors to the tumors.
Relative incidence of various histopathological types of colorectal cancer. The vast majority of colorectal cancers are adenocarcinomas.
References
- ↑ Cancer Genome Atlas Network (19 July 2012). "Comprehensive molecular characterization of human colon and rectal cancer". Nature. 487 (7407): 330–337. Bibcode:2012Natur.487..330T. doi:10.1038/nature11252. PMC 3401966. PMID 22810696.
- ↑ Colorectal Cancer Incidence, Mortality and Prevalence Worldwide in 2008 — Summary. Available from: Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. (2010) GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer. Accessed on 11 Oct 2012.