Combinatorial chemistry

Combinatorial chemistry is a branch of chemistry that creates a large number of different compounds using standardized reactions. Very often robots are used for synthesis. After synthesis, the compounds with the desired properties are kept. The main use for the procedure is Medicinal chemistry and pharmacology.

Combinatorial Chemistry Media

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  Peptides forming in cycles 3 and 4

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  Flow diagram of the split-mix combinatorial synthesis

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  Use of a solid-supported polyamine to scavenge excess reagent

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  Example of a solid-phase supported dye to signal ligand binding

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  Cleavage of the carbon-silicon bond provides products without attached silicon.

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  Compounds that can be synthesized from solid-phase bound imines

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  Recursive deconvolution. Blue, yellow and red circles: amino acids, Green circle: solid support

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  Positional scanning. Full trimer peptide library made from 3 amino acids and its 9 sublibraries. The first row shows the coupling positions.

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  A 27-member tripeptide full library and the three omission libraries. The color circles are amino acids.