Combinatorial chemistry

Combinatorial chemistry is a branch of chemistry that creates a large number of different compounds using standardized reactions. Very often robots are used for synthesis. After synthesis, the compounds with the desired properties are kept. The main use for the procedure is Medicinal chemistry and pharmacology.

Combinatorial Chemistry Media

• Cycle 3,4 vágott.jpg

  Peptides forming in cycles 3 and 4

• Flow diagram of the split-mix combinatorial synthesis

• Use of a solid-supported polyamine to scavenge excess reagent

• Example of a solid-phase supported dye indicating ligand binding.tif

  Example of a solid-phase supported dye to signal ligand binding

• Using a traceless linker as described by Ellman.tif

  Cleavage of the carbon-silicon bond provides products without attached silicon.

• Products that can be synthesized from imines.tif

  Compounds that can be synthesized from solid-phase bound imines

• Recursive deconvolution.png

  Recursive deconvolution. Blue, yellow and red circles: amino acids, Green circle: solid support

• Positional scanning. Full trimer peptide library made from 3 amino acids and its 9 sublibraries. The first row shows the coupling positions.

• A 27-member tripeptide full library and the three omission libraries. The color circles are amino acids.