Fatal insomnia

Fatal familial insomnia is a prion disease. It is 100% fatal. Victims will not sleep for months on end before eventual death.

Fatal Insomnia Media

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  Idiogram of chromosome 20 showing gene PRP location

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  Hypnogram comparing the sleep pattern of a healthy control with five FFI patients, who display decreased sleep efficiency and disrupted sleep cycles. [W: wake; R: REM; N1-3: NREM sleep stages].

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  Timeline of an FFI patient (same as the one above this one)