Group transfer reaction

A Group transfer reaction is pericyclic reaction where one pi bond is converted to one sigma bond, at the same time that a sigma bond migrates.

The best known group transfer reaction is the ene reaction.

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Group Transfer Reaction Media

Figure1newene.png

Figure 2. Generic ene reaction.
Reduction diimide.png

Figure 3. Generic mechanism of a reduction with diimide adapted from Mandal.
Protein adenylylation.png

Figure 4. Scheme of protein adenylylation of threonine and tyrosine side chains, a biological application of group transfer reactions. This figure is adapted from Hedberg and Itzen.
The ene reduction of an alkene using OYE2 ene reductase.png

Figure 5. The ene reduction of an alkene using OYE2 ene reductase. This figure is adapted from an article on the Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis.