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Methotrexate




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Methotrexate
Systematic (IUPAC) name
(2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Identifiers
CAS number 59-05-2
ATC code L01BA01 L04AX03
PubChem 126941
DrugBank APRD00353
ChemSpider 112728
Chemical data
Formula C20H22N8O5 
Mol. mass 454.44 g/mol
Pharmacokinetic data
Bioavailability 17–90%
Metabolism hepatic
Half life 3–15 hours (dose dependent)
Excretion renal 48–100%
Therapeutic considerations
Pregnancy cat.

D(AU) X(US)

Legal status

Prescription Only (S4)(AU) POM(UK) -only(US)

Routes , IV, IM, SC, intrathecal

Methotrexate is a drug. It is used to treat cancer and other autoimmune diseases. It can also be used to cause a medical abortion in the early stages of pregnancy.