Organocatalysis
In organic chemistry, organocatalysis is a form of catalysis where the rate of a chemical reaction grows by an organic catalyst. They are made up of carbon, hydrogen, sulfur and other nonmetal elements found in organic compounds.[1][2][3][4][5][6]
Organic chemists David MacMillan and Benjamin List both won the 2021 Nobel Prize in Chemistry for their work on asymmetric organocatalysis.[7]
Organocatalysis Media
Justus von Liebig's synthesis of oxamide from dicyan and water represents the first organocatalytic reaction, with acetaldehyde further identified as the first discovered pure "organocatalyst", which act similarly to the then-named "ferments", now known as enzymes.
- Organocatalytic
Imidazolidinone Catalysts
Iminium activation MacMillan
Asymmetric warfarin synthesis Jørgensen 2003
Asymmetric Vinyl Alkylation Lee 2007
References
- ↑ Berkessel, A.. Asymmetric Organocatalysis (2005). Weinheim: Wiley-VCH. ISBN 978-3-527-30517-9.
- ↑ Special Issue: List, Benjamin. Organocatalysis. Chem. Rev. 107 (12) (2007). p. 5413–5883. doi:10.1021/cr078412e.
- ↑ Peter I. Dalko. In the Golden Age of Organocatalysis. Angew. Chem. Int. Ed. 43 (39) (2004). p. 5138–5175. doi:10.1002/anie.200400650.
- ↑ Matthew J. Gaunt. Enantioselective organocatalysis. Drug Discovery Today 12 (1/2) (2007). p. 8–27. doi:10.1016/j.drudis.2006.11.004.
- ↑ Dieter Enders. Asymmetric Organocatalytic Domino Reactions. Angew. Chem. Int. Ed. 46 (10) (2007). p. 1570–1581. doi:10.1002/anie.200603129.
- ↑ Peter I. Dalko. Enantioselective Organocatalysis. Angew. Chem. Int. Ed. 40 (20) (2001). p. 3726–3748. doi:<3726::AID-ANIE3726>3.0.CO;2-D 10.1002/1521-3773(20011015)40:20<3726::AID-ANIE3726>3.0.CO;2-D.
- ↑ 2021 Nobel Prize in chemistry. Nobel Prize. Retrieved 6 October 2021.
