Organocatalysis
In organic chemistry, organocatalysis is a form of catalysis where the rate of a chemical reaction grows by an organic catalyst. They are made up of carbon, hydrogen, sulfur and other nonmetal elements found in organic compounds.[1][2][3][4][5][6]
Organic chemists David MacMillan and Benjamin List both won the 2021 Nobel Prize in Chemistry for their work on asymmetric organocatalysis.[7]
Organocatalysis Media
Justus von Liebig's synthesis of oxamide from dicyan and water represents the first organocatalytic reaction, with acetaldehyde further identified as the first discovered pure "organocatalyst", which act similarly to the then-named "ferments", now known as enzymes.
- Organocatalytic
Imidazolidinone Catalysts
Iminium activation MacMillan
Asymmetric warfarin synthesis Jørgensen 2003
Asymmetric Vinyl Alkylation Lee 2007
References
- ↑ Berkessel, A.; Groeger, H. (2005). Asymmetric Organocatalysis. Weinheim: Wiley-VCH. ISBN 978-3-527-30517-9.
- ↑ Special Issue: List, Benjamin (2007). "Organocatalysis". Chem. Rev. 107 (12): 5413–5883. doi:10.1021/cr078412e.
- ↑ Peter I. Dalko; Lionel Moisan (2004). "In the Golden Age of Organocatalysis". Angew. Chem. Int. Ed. 43 (39): 5138–5175. doi:10.1002/anie.200400650. PMID 15455437.
- ↑ Matthew J. Gaunt; Carin C.C. Johansson; Andy McNally; Ngoc T. Vo (2007). "Enantioselective organocatalysis". Drug Discovery Today. 12 (1/2): 8–27. doi:10.1016/j.drudis.2006.11.004. PMID 17198969.
- ↑ Dieter Enders; Christoph Grondal; Matthias R. M. Hüttl (2007). "Asymmetric Organocatalytic Domino Reactions". Angew. Chem. Int. Ed. 46 (10): 1570–1581. doi:10.1002/anie.200603129. PMID 17225236.
- ↑ Peter I. Dalko; Lionel Moisan (2001). "Enantioselective Organocatalysis". Angew. Chem. Int. Ed. 40 (20): 3726–3748. doi:10.1002/1521-3773(20011015)40:20<3726::AID-ANIE3726>3.0.CO;2-D. PMID 11668532.
- ↑ "2021 Nobel Prize in chemistry". Nobel Prize. Retrieved 6 October 2021.
