Raphe nuclei

The Raphe nuclei (singular = Raphe nucleus) are a cluster of nuclei in the hindbrain which release a neurotransmitter called serotonin (5-HT). The serotonin molecules get sent all over the brain, where they're needed for all sorts of roles.^[1] 'Selective serotonin reuptake inhibitor' (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets.^[2] Many opioids (drugs that calm people down) can act on the Raphe nuclei to secrete too much 5-HT.

Raphe Nuclei Media

Dopamine and serotonin pathways in the brain

References

↑ George J. Siegel, ed. (1999). "Understanding the neuroanatomical organization of serotonergic cells in brain provides insight into the functions of this neurotransmitter". Basic neurochemistry (6th ed.). Lippincott Williams and Wilkins. ISBN 0-397-51820-X.
↑ Briley, M; Moret, C (October 1993). "Neurobiological mechanisms involved in antidepressant therapies". Clin Neuropharmacol. 16 (5): 387–400. doi:10.1097/00002826-199310000-00002. PMID 8221701.

[1] George J. Siegel, ed. (1999). "Understanding the neuroanatomical organization of serotonergic cells in brain provides insight into the functions of this neurotransmitter". Basic neurochemistry (6th ed.). Lippincott Williams and Wilkins. ISBN 0-397-51820-X.

[2] Briley, M; Moret, C (October 1993). "Neurobiological mechanisms involved in antidepressant therapies". Clin Neuropharmacol. 16 (5): 387–400. doi:10.1097/00002826-199310000-00002. PMID 8221701.

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