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[[Image:Dendritic cell.JPG|thumb|right|230px|A dendritic cell]]

[[Image:Dendritic cell.JPG|thumb|right|230px|A dendritic cell]]

'''Dendritic cells''' (DCs) are [[white blood cells]] forming part of the [[mammal]]ian [[immune system]]. They process [[antigen]] material from [[pathogen]]s and put it on their surface. There it touches other cells of the immune system.  So, dendritic cells are antigen-presenting cells. They act as [[wikt:messenger|messengers]] between the [[Innate immune system|innate]] and [[adaptive immune system]]s.

'''Dendritic cells''' (DCs) are [[white blood cells]] forming part of the [[mammal]]ian [[immune system]]. They process [[antigen]] material from [[pathogen]]s and put it on their surface. There it touches other cells of the immune system.  So, dendritic cells are antigen-presenting cells. They act as [[messenger|messengers]] between the [[Innate immune system|innate]] and [[adaptive immune system]]s.

Dendritic cells are present in [[Tissue (biological)|tissues]] in contact with the external environment. These tissues are the [[skin]], and the inner lining of the [[nose]], [[lungs]], [[stomach]] and [[intestine]]s. They can also be found in an immature state in the [[blood]].

Dendritic cells are present in [[Tissue (biological)|tissues]] in contact with the external environment. These tissues are the [[skin]], and the inner lining of the [[nose]], [[lungs]], [[stomach]] and [[intestine]]s. They can also be found in an immature state in the [[blood]].

==History==

==History==

Dendritic cells were first described by [[Paul Langerhans]] (Langerhans cells) in the late nineteenth century. It wasn't until 1973, however, that [[Ralph Steinman]] and Zanvil  Cohn gave them the name 'dendritic cells'.<ref name=Steinman>{{cite journal |author=Steinman R.M. & Cohn Z.A. |title=Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution |journal=J. Exp. Med. |volume=137 |issue=5 |pages=1142–62 |year=1973 |pmid=4573839|doi=10.1084/jem.137.5.1142 |pmc=2139237}}</ref> For discovering the central role of dendritic cells in the adaptive immune response,<ref name="pmid9521319">{{cite journal |author=Banchereau J. & Steinman R.M. |title=Dendritic cells and the control of immunity |journal=Nature |volume=392 |issue=6673 |pages=245–52 |year=1998 |pmid=9521319 |doi=10.1038/32588 }}</ref> Steinman was awarded the [[Albert Lasker Award]] in 2007,<ref name="Lasker2007">{{cite web |url=http://www.laskerfoundation.org/awards/2007basic.htm |title=The Lasker Foundation - 2007 Awards |access-date=2010-11-27}}</ref> and the [[Nobel Prize in Physiology or Medicine]] in 2011.<ref name="Nobel2011">{{cite web |url=http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/# |title=Nobel Prize in Physiology or Medicine for 2011"}}</ref>

Dendritic cells were first described by [[Paul Langerhans]] (Langerhans cells) in the late nineteenth century. It wasn't until 1973, however, that [[Ralph Steinman]] and Zanvil  Cohn gave them the name 'dendritic cells'.<ref name=Steinman>{{cite journal |author=Steinman R.M. & Cohn Z.A. |title=Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution |journal=J. Exp. Med. |volume=137 |issue=5 |pages=1142–62 |year=1973 |pmid=4573839|doi=10.1084/jem.137.5.1142 |pmc=2139237}}</ref> For discovering the central role of dendritic cells in the adaptive immune response,<ref name="pmid9521319">{{cite journal |author=Banchereau J. & Steinman R.M. |title=Dendritic cells and the control of immunity |journal=Nature |volume=392 |issue=6673 |pages=245–52 |year=1998 |pmid=9521319 |doi=10.1038/32588 |s2cid=4388748 }}</ref> Steinman was awarded the [[Albert Lasker Award]] in 2007,<ref name="Lasker2007">{{cite web |url=http://www.laskerfoundation.org/awards/2007basic.htm |title=The Lasker Foundation - 2007 Awards |access-date=2010-11-27}}</ref> and the [[Nobel Prize in Physiology or Medicine]] in 2011.<ref name="Nobel2011">{{cite web |url=http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/# |title=Nobel Prize in Physiology or Medicine for 2011"}}</ref>

== References ==

== References ==