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| | '''Dendritic cells''' (DCs) are [[white blood cells]] forming part of the [[mammal]]ian [[immune system]]. They process [[antigen]] material from [[pathogen]]s and put it on their surface. There it touches other cells of the immune system. So, dendritic cells are antigen-presenting cells. They act as [[messenger|messengers]] between the [[Innate immune system|innate]] and [[adaptive immune system]]s. | | '''Dendritic cells''' (DCs) are [[white blood cells]] forming part of the [[mammal]]ian [[immune system]]. They process [[antigen]] material from [[pathogen]]s and put it on their surface. There it touches other cells of the immune system. So, dendritic cells are antigen-presenting cells. They act as [[messenger|messengers]] between the [[Innate immune system|innate]] and [[adaptive immune system]]s. |
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| − | Dendritic cells are present in [[Tissue (biological)|tissues]] in contact with the external environment. These tissues are the [[skin]], and the inner lining of the [[nose]], [[lungs]], [[stomach]] and [[intestine]]s. They can also be found in an immature state in the [[blood]]. | + | Dendritic cells are present in [[Tissue (biological)|tissues]] in contact with the external environment. These tissues are the [[skin]], and the inner lining of the [[nose]], [[lungs]], [[stomach]] and [[intestine]]s. They can also be found in an immature and mature state in the [[blood]]. |
| | == Young dentritics == | | == Young dentritics == |
| | Dedritic cells develop from [[monocyte]]s, white blood cells which circulate in the body. Depending on the signal, monocytes turn into either dendritic cells or [[macrophage]]s. The monocytes are formed from [[stem cell]]s in the [[bone marrow]]. | | Dedritic cells develop from [[monocyte]]s, white blood cells which circulate in the body. Depending on the signal, monocytes turn into either dendritic cells or [[macrophage]]s. The monocytes are formed from [[stem cell]]s in the [[bone marrow]]. |
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| | == Dendritic Cell Media == | | == Dendritic Cell Media == |
| | <gallery widths='160px' heights='100%' mode='traditional' caption=''> | | <gallery widths='160px' heights='100%' mode='traditional' caption=''> |
| − | File:Centrocyte, centroblast and follicular dendritic cell in a follicular lymphoma.jpg|Histologic comparison of cell types in a [[germinal center]], including follicular dendritic cells, H&E stain:- '''[[Centrocyte]]s''' are small to medium size with angulated, elongated, cleaved, or twisted nuclei.- '''[[Centroblast]]s''' are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.- '''[[Follicular dendritic cell]]s''' have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.
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| | File:Immune_Cells_Development.pdf|Diagram of hematopoiesis from HSC, showing a separate dendritic cell lineage via CDP (Common Dendritic-cell Progenitor). | | File:Immune_Cells_Development.pdf|Diagram of hematopoiesis from HSC, showing a separate dendritic cell lineage via CDP (Common Dendritic-cell Progenitor). |
| | </gallery> | | </gallery> |
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| | [[Category:Blood cells]] | | [[Category:Blood cells]] |
| | [[Category:Immunology]] | | [[Category:Immunology]] |
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| | + | <!-- checked on 10/07/2023 08:15:03 pm --> |