Warfarin
Warfarin (sometimes sold as Coumadin) is a powerful water-soluble compound. It prevents blood from clotting. It does that by reducing the production of factors by the liver that promote clotting. It is called an "anticoagulant agent". It is a powerful rat poison. In concentrated form, it causes bleeding of internal organs which leads to death.[1]
It is also used, in very low doses, to prevent thrombosis in humans.[2] This is the local coagulation or clotting of the blood in the circulatory system. In such cases, it makes heart attacks, strokes, and pulmonary embolism less likely.[2] The degree of anticoagulation is monitored by blood tests.
Warfarin Media
Vitamin K1-warfarin interaction effect: When warfarin levels are high, people have more risk of bleeding. Conversely, lower levels of warfarin lead to increased risk of blood clots.
Acyclic tautomer (left) and cyclic hemiketal tautomer (right)
(R)-Warfarin Structural Formula V1
(S)-Warfarin Structural Formula V1
3 mg (blue), 5 mg (pink) and 1 mg (brown) warfarin tablets (UK colours)
Warning label on a tube of rat poison laid on a dike of the Scheldt River in Steendorp, Belgium: The tube contains bromadiolone, a second-generation ("super-warfarin") anticoagulant.
-Warfarin_Structural_Formula_V1.svg)
-Warfarin_Structural_Formula_V1.svg)
References
- ↑ Tornkvist, Max; Smith, J. Gustav; Labaf, Ashkan (2018-02-01). "Current evidence of oral anticoagulant reversal: A systematic review". Thrombosis Research. 162: 22–31. doi:10.1016/j.thromres.2017.12.003. ISSN 0049-3848. PMID 29258056.
- ↑ 2.0 2.1 "Warfarin Monograph for Professionals". Drugs.com. Retrieved 2022-11-14.