Wilms tumor
Wilms' tumor, also known as Nephroblastoma, is a form of kidney cancer that occurs most often in children. It has an excellent prognosis, with 90% of patients living for more than five years after being diagnosed.
| Wilms' tumor | |
|---|---|
| Classification and external resources | |
 Cut section showing two halves of an infected kidney with a Wilms' tumour. Note the prominent septa subdividing the sectioned surface and the protrusion of tumor into the renal pelvis, resembling botryoid rhabdomyosarcoma. | |
| ICD-10 | C64. |
| ICD-9 | 189.0 |
| ICD-O: | M8960/3 |
| OMIM | 194070 607102 |
| DiseasesDB | 8896 |
| MedlinePlus | 001575 |
| eMedicine | med/3093 ped/2440 |
| MeSH | D009396 |
Treatment
In general, Wilms' tumor is curable. If the tumor is only in the kidney, it can be removed along with the whole kidney. This procedure is called a nephrectomy. During the operation, the surgeon checks if the other kidney has a tumor. If there are tumors in both kidneys, a piece of the tumor will be removed. After the surgery, the child is given some chemotherapy drugs like Dactinomycin. This drug is also known by its trade name Cosmegen.
Both operation and chemotherapy are sometimes used.[1]
Wilms Tumor Media
Low magnification micrograph of a Wilms' tumor infiltrating the renal parenchyma. It shows the characteristic triphasic pattern consisting of tubules, solid sheets of small round cells, and stroma. H&E stain. The surrounding renal parenchyma is more eosinophilic (pink) than the rather grey tumor stroma.
CT scan of 11 cm Wilms' tumor of right kidney in 13-month-old.
References
- ↑ Metzger ML, Dome JS (2005). "Current therapy for Wilms' tumor". Oncologist. 10 (10): 815–26. doi:10.1634/theoncologist.10-10-815. PMID 16314292. Archived from the original on 2010-12-08. Retrieved 2012-06-20.