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Chlorpromazine
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| Chlorpromazine
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| Systematic (IUPAC) name | |
| 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine | |
| Identifiers | |
| CAS number | 50-53-3 (free base) 69-09-0 (hydrochloride) |
| ATC code | N05AA01 |
| PubChem | 2726 |
| DrugBank | DB00477 |
| ChemSpider | 2625 |
| Chemical data | |
| Formula | C17H19ClN2S |
| Mol. mass | 318.86 g/mol (free base) 355.33 g/mol (hydrochloride) |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | 10–80% (Oral; large interindividual variation)[1] |
| Protein binding | 90–99%[1] |
| Metabolism | Liver, mostly CYP2D6-mediated[1] |
| Half life | 30 hours |
| Excretion | Urine (43–65% in 24 hrs)[1] |
| Therapeutic considerations | |
| Licence data | |
| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Oral (tablets and syrup available), rectal, IM, IV infusion |
Chlorpromazine is an antipsychotic drug. It is the oldest such drug. It was developed in 1950. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.
References
- ↑ 1.0 1.1 1.2 1.3 "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Archived from the original on 30 March 2017. https://web.archive.org/web/20170330162812/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05882-3. Retrieved 8 December 2013.
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