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Skeletal formula of chlorpromazine
Ball-and-stick model of the chlorpromazine molecule
Systematic (IUPAC) name
CAS number 50-53-3 (free base)
69-09-0 (hydrochloride)
ATC code N05AA01
PubChem 2726
DrugBank DB00477
ChemSpider 2625
Chemical data
Formula C17H19ClN2S 
Mol. mass 318.86 g/mol (free base)
355.33 g/mol (hydrochloride)
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 10–80% (Oral; large interindividual variation)[1]
Protein binding 90–99%[1]
Metabolism Liver, mostly CYP2D6-mediated[1]
Half life 30 hours
Excretion Urine (43–65% in 24 hrs)[1]
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat.


Legal status

Prescription only

Routes Oral (tablets and syrup available), rectal, IM, IV infusion

Chlorpromazine is an antipsychotic drug. It is the oldest such drug. It was developed in 1950. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.


  1. 1.0 1.1 1.2 1.3 "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Archived from the original on 30 March 2017. Retrieved 8 December 2013.