Downtown
Downtown (called a city centre in British English) is a word used in North America which refers to the main part of a city. It is usually the central business district where most commercial and office areas are; many of them being in skyscrapers. Tourism also concentrates there.
Downtown Media
Lower Manhattan at the southern end of Manhattan Island also has a low topographic elevation -- it was New York City's original down town, and is the fourth-most populous downtown in the United States, and is often the colloquial signification of the term Downtown.
Center City, Philadelphia, the second-most populous downtown in the United States
Chicago Loop, the fifth-most populous downtown in the United States
Downtown Los Angeles, the third-most populous downtown in the United States
Timelapse video of Downtown Seattle from atop a Community Transit double-decker bus