Ivermectin
Ivermectin is a medication used to treat parasite infestations. They can treat head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis.[1][2]
During the COVID-19 pandemic, misinformation has been widely spread saying that ivermectin is beneficial for treating and preventing COVID-19.[3][4] Though this cannot be proven to be true[5][6] or false. General confusion, the "infodemic" and the lack of effective treatment seemingly attributed to individuals to repurpose various medications - including ivermectin - on the market without approved indications for COVID-19 as potentially effective treatments and purchase them from unapproved websites.[7]
Ivermectin Media
Ivermectin (IVM) bound to a C. elegans GluClR. IVM molecules interact with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl−) ions into the cell. (The plasma membrane is represented as a blue–pink gradient.) From PDB 3RHW.
Avermectins produced by fermentation are the chemical starting point for ivermectin
References
- ↑ Drug Discovery a History (2005). Chichester: John Wiley & Sons. p. 333. ISBN 978-0-470-01552-0.
- ↑ U.S. Centers for Disease Control and Prevention (CDC). Ascariasis – Resources for Health Professionals. U.S. Centers for Disease Control and Prevention (CDC) (August 23, 2019). Retrieved December 28, 2019.
- ↑ "Anatomy of a conspiracy theory: how misinformation travels on Facebook". The Guardian. https://www.theguardian.com/australia-news/ng-interactive/2021/mar/11/anatomy-of-a-conspiracy-theory-how-misinformation-travels-on-facebook. Retrieved May 26, 2021.
- ↑ "Fact-checking claim about the use of ivermectin to treat COVID-19". PolitiFact (Washington, DC). https://www.politifact.com/factchecks/2021/apr/23/instagram-posts/fact-checking-claim-about-use-ivermectin-treat-cov/. Retrieved May 26, 2021.
- ↑ EMA advises against use of ivermectin for the prevention or treatment of COVID-19 outside randomised clinical trials (March 22, 2021)European Medicines Agency.
- ↑ Misleading clinical evidence and systematic reviews on ivermectin for COVID-19. BMJ Evidence-Based Medicine 27 (3) (April 22, 2021). p. 156–158. doi:10.1136/bmjebm-2021-111678.
- ↑ Fittler, András. Effect of Infodemic Regarding the Illegal Sale of Medications on the Internet: Evaluation of Demand and Online Availability of Ivermectin during the COVID-19 Pandemic (in en). International Journal of Environmental Research and Public Health 18 (14) (January 2021). p. 7475. doi:10.3390/ijerph18147475.
