Polypeptide

Tetrapeptide structural formulae N-terminus (Green) (N-terminus) and C-terminus (Blue) (C-terminus)

A polypeptide is a string or linear chain of amino acids linked together. Amino acids are the basic building blocks of proteins.^[1] A single polypeptide chain might make up the entire primary structure of a simple protein;^[2] more complex proteins are formed when two or more polypeptides link together. Each protein is a polymer of amino acids.^[3]^[4]

Polypeptides are made when mRNA is translated, a process involving ribosomes, tRNA and amino acids.

Polypeptide Media

Drosomycin, an example of a peptide
Solid-phase peptide synthesis on a rink amide resin using Fmoc-α-amine-protected amino acid
Example of a protein (orange) and peptide (green) interaction. Obtained from Propedia: a peptide-protein interactions database.
A tripeptide (example Val-Gly-Ala) with green marked amino end (L-valine) and blue marked carboxyl end (L-alanine)

References

↑ Abba J. Kastin, ed. (2013). Handbook of Biologically Active Peptides (2nd ed.). Elsevier Science. ISBN 978-0-12-385095-9.
↑ Torres AM, Menz I, Alewood PF, et al. (July 2002). "D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus". FEBS Letters. 524 (1–3): 172–6. doi:10.1016/S0014-5793(02)03050-8. PMID 12135762. S2CID 3015474.
↑ Duquesne S, Destoumieux-Garzón D, Peduzzi J, Rebuffat S (August 2007). "Microcins, gene-encoded antibacterial peptides from enterobacteria". Natural Product Reports. 24 (4): 708–34. doi:10.1039/b516237h. PMID 17653356.
↑ Pons M, Feliz M, Antònia Molins M, Giralt E (May 1991). "Conformational analysis of bacitracin A, a naturally occurring lariat". Biopolymers. 31 (6): 605–12. doi:10.1002/bip.360310604. PMID 1932561. S2CID 10924338.

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[1] Abba J. Kastin, ed. (2013). Handbook of Biologically Active Peptides (2nd ed.). Elsevier Science. ISBN 978-0-12-385095-9.

[2] Torres AM, Menz I, Alewood PF, et al. (July 2002). "D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus". FEBS Letters. 524 (1–3): 172–6. doi:10.1016/S0014-5793(02)03050-8. PMID 12135762. S2CID 3015474.

[3] Duquesne S, Destoumieux-Garzón D, Peduzzi J, Rebuffat S (August 2007). "Microcins, gene-encoded antibacterial peptides from enterobacteria". Natural Product Reports. 24 (4): 708–34. doi:10.1039/b516237h. PMID 17653356.

[4] Pons M, Feliz M, Antònia Molins M, Giralt E (May 1991). "Conformational analysis of bacitracin A, a naturally occurring lariat". Biopolymers. 31 (6): 605–12. doi:10.1002/bip.360310604. PMID 1932561. S2CID 10924338.

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