Positive-sense single-stranded RNA virus
A positive-sense single-stranded RNA virus (or (+)ssRNA virus) is a virus which has positive sense single stranded RNA as its genetic material. They can be positive or negative. This depends on the polarity of the RNA. The positive-sense viral RNA genome can serve as messenger RNA and can be translated into protein in the host cell.
Many of the known viruses are positive-sense RNA viruses, including the hepacivirus C, West Nile virus, dengue virus, SARS and MERS coronaviruses, and SARS-CoV-2[1] as well as less serious pathogens such as the rhinoviruses that cause the common cold.[2][3][4]
Positive-sense Single-stranded RNA Virus Media
Life cycle of Japanese encephalitis virus a +ssRNA virus: attachment, endocytosis, membrane fusion, uncoating, translation, RNA replication, assembly, maturation, and release.
Mechanisms of replicative and nonreplicative RNA recombination.
Phylogenetic tree with phylum branches highlighted. Negarnaviricota (brown), Duplornaviricota (green), Kitrinoviricota (pink), Pisuviricota (blue), and Lenarviricota (yellow).
False-color Transmission electron micrograph of a SARS-CoV-2 virion. Coronaviruses like SARS-CoV-2 fall in the phylum Pisuviricota.
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References
- ↑ Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. (February 2020). "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding". Lancet. 395 (10224): 565–574. doi:10.1016/S0140-6736(20)30251-8. PMC 7159086. PMID 32007145.
- ↑ Nagy PD, Pogany J (December 2011). "The dependence of viral RNA replication on co-opted host factors". Nature Reviews. Microbiology. 10 (2): 137–49. doi:10.1038/nrmicro2692. PMC 7097227. PMID 22183253.
- ↑ Ahlquist P, Noueiry AO, Lee WM, Kushner DB, Dye BT (August 2003). "Host factors in positive-strand RNA virus genome replication". Journal of Virology. 77 (15): 8181–6. doi:10.1128/JVI.77.15.8181-8186.2003. PMC 165243. PMID 12857886.
- ↑ Modrow S, Falke D, Truyen U, Schätzl H (2013). "Viruses with Single-Stranded, Positive-Sense RNA Genomes". Molecular virology. Berlin, Heidelberg: Springer. pp. 185–349. doi:10.1007/978-3-642-20718-1_14. ISBN 978-3-642-20718-1. S2CID 82608215.