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Positive-sense single-stranded RNA virus

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A positive-sense single-stranded RNA virus (or (+)ssRNA virus) is a virus which has positive sense single stranded RNA as its genetic material. They can be positive or negative. This depends on the polarity of the RNA. The positive-sense viral RNA genome can serve as messenger RNA and can be translated into protein in the host cell.

Many of the known viruses are positive-sense RNA viruses, including the hepacivirus C, West Nile virus, dengue virus, SARS and MERS coronaviruses, and SARS-CoV-2[1] as well as less serious pathogens such as the rhinoviruses that cause the common cold.[2][3][4]


  1. "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding". Lancet 395 (10224): 565–574. February 2020. doi:10.1016/S0140-6736(20)30251-8 . PMID 32007145 . 
  2. "The dependence of viral RNA replication on co-opted host factors". Nature Reviews. Microbiology 10 (2): 137–49. December 2011. doi:10.1038/nrmicro2692 . PMC 7097227 . PMID 22183253 . 
  3. "Host factors in positive-strand RNA virus genome replication". Journal of Virology 77 (15): 8181–6. August 2003. doi:10.1128/JVI.77.15.8181-8186.2003 . PMC 165243 . PMID 12857886 . 
  4. Modrow, Susanne; Falke, Dietrich; Truyen, Uwe; Schätzl, Hermann (2013). "Viruses with Single-Stranded, Positive-Sense RNA Genomes". Molecular virology. Berlin, Heidelberg: Springer. pp. 185–349. doi:10.1007/978-3-642-20718-1_14 . ISBN 978-3-642-20718-1 .