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Psychoneuroimmunology (PNI) is the study of the interaction between psychological processes and the nervous and immune systems of the human body.[1] PNI takes an interdisciplinary approach.

The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health.


Interest in the relationship between psychiatric syndromes or symptoms and immune function has been a consistent theme since the beginning of modern medicine.

Claude Bernard, a French physiologist, founded the concept milieu interieur in the mid 1800s. In 1865, Bernard described the perturbation of this internal state “… there are protective functions of organic elements holding living materials in reserve and maintaining without interruption humidity, heat and other conditions indispensable to vital activity. Sickness and death are only a dislocation or perturbation of that mechanism." (Bernard, 1865)

Walter Cannon, a professor of physiology at Harvard University coined the term homeostasis in his book The Wisdom of the Body in 1932. In his work with animals Cannon observed that any change of emotional state in the beast, such as anxiety, distress, or rage was accompanied by total cessation of movements of the stomach (Bodily Changes in Pain, Hunger, Fear and Rage, 1915). These studies into the relationship between the effects of emotions and perceptions on the autonomic nervous system, the responses that led to the freeze, fight or flight response.

Birth of psychoneuroimmunology

In 1975 Robert Ader and Nicholas Cohen advanced PNI with a demonstration of classic conditioning of the immune function, and coined the term "psychoneuroimmunology".[2][3] Ader was investigating how long conditioned responses might last in laboratory rats. The highly reproducible results showed that conditioned rats exposed to the conditioned stimulus were immuno suppressed. In other words, a signal via the nervous system (taste) was affecting immune function. This was one of the first scientific experiments that demonstrated that the nervous system can affect the immune system.

In 1981 David Felten, then working at the Indiana University of Medicine, discovered a network of nerves leading to blood vessels as well as cells of the immune system. The researchers also found nerves in the thymus and spleen terminating near clusters of lymphocytes, macrophages and mast cells, all of which help control immune function. This discovery provided one of the first indications of how neuro-immune interaction occurs.

Ader, Cohen and Felten went on to edit the groundbreaking book Psychoneuroimmunology in 1981, which laid out the underlying premise that the brain and immune system represent a single, integrated system of defense.

Link between stress and disease

Stressors can produce profound health consequences. In one epidemiological study, for example, all-cause mortality increased in the month following a severe stressor – the death of a spouse.[4] Theorists propose that stressful events trigger cognitive and affective responses which, in turn, induce sympathetic nervous system and endocrine changes. These ultimately impair immune function.[5][6] Potential health consequences are broad, but include rates of infection,[7][8] HIV progression,[9][10] and cancer incidence and progression.[4][11][12]


  1. Michael Irwin, Kavita Vedhara (2005). Human Psychoneuroimmunology. Oxford University Press. ISBN 978-0-19-856884-1 . 
  2. R Ader and N Cohen. 1975.Behaviorally conditioned immunosuppression. Psychosomatic Medicine. 37, 333-340.
  3. "Robert Ader, Founder of Psychoneuroimmunology, Dies". University of Rochester Medical Center. 2011-12-20. Retrieved 2011-12-20. 
  4. 4.0 4.1 Kaprio J. Koskenvuo M. and Rita H. 1987. Mortality after bereavement: a prospective study of 95,647 widowed persons. American Journal of Public Health 77(3), 283-7.
  5. Chrousos G.P. and Gold P.W. 1992. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267, 1244-52.
  6. Glaser R. and Kiecolt-Glaser J.K. 1994. Handbook of human stress and immunity. San Diego: Academic Press.
  7. Cohen S; Tyrrell D.A. and Smith A.P. 1991. Psychological stress and susceptibility to the common cold. The New England Journal of Medicine 325(9), 606-12.
  8. Cohen S. and Williamson G.M. 1991. Stress and infectious disease in humans. Psychological Bulletin 109(1), 5-24.
  9. Leserman J. et al 2000. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. The American Journal of Psychiatry 157(8), 1221-8.
  10. Leserman J. et al 1999. Progression to AIDS: the effects of stress, depressive symptoms, and social support. Psychosomatic Medicine 61(3), 397-406.
  11. Andersen B.L; Kiecolt-Glaser J.K. and Glaser R. 1994. A biobehavioral model of cancer stress and disease course. American Psychologist 49(5), 389-404.
  12. Kiecolt-Glaser J.K. and Glaser R. 1999. Psychoneuroimmunology and cancer: fact or fiction? European Journal of Cancer 35, 1603-7.