Tiotropium bromide
Tiotropium bromide (brand names Braltus, Spiriva, Spiriva Respimat in the UK[1]) is a drug which belongs to a group of medicines called anticholinergic bronchodilators. It is used as a bronchodilator. It helps people with COPD and asthma[2][1] as preventative drug, known as a preventive inhaler - it is a long-acting drug and usually only needs to be taken once a day.[1]
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Tiotropium bromide
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | 136310-93-5 186691-13-4 (cation) |
| ATC code | R03BB04 |
| PubChem | 5487426 |
| DrugBank | DBSALT000348 |
| ChemSpider | 10482095 |
| Chemical data | |
| Formula | ? |
| Mol. mass | ? |
| Pharmacokinetic data | |
| Bioavailability | 19.5% (inhalation) |
| Metabolism | Liver 25% (CYP2D6, CYP3A4) |
| Half life | 5–6 days |
| Excretion | Kidney |
| Therapeutic considerations | |
| Licence data | |
| Pregnancy cat. |
B1(AU) |
| Legal status | |
| Routes | By mouth, inhalation by mouth |
It is used when people have trouble breathing to help them breathe better, such as easing coughing, wheezing and feeling breathless in asthma. It is used by breathing it through the mouth.[2] Its effects last for 24 hours.[2][3]
Some side effects can happen from using it, such as having a dry mouth, runny nose, headache, or having problems with breathing. There are also serious side effects that could happen, such as angioedema and bronchospasms. It has not been proven to be bad to use while pregnant, but this has not been studied very much.[4] In 2020, there were more than 5 million prescriptions for tiotropium bromide in the United States.[5]
References
- ↑ 1.0 1.1 1.2 "About tiotropium inhalers". nhs.uk. 2023-11-02. Retrieved 2024-06-02.
- ↑ 2.0 2.1 2.2 Committee, Joint Formulary (2018-09-21). BNF 76 September 2018-March 2019. Pharmaceutical Press. ISBN 978-0-85711-338-2.
- ↑ "Tiotropium Monograph for Professionals". Drugs.com. Retrieved 2022-11-15.
- ↑ "Tiotropium Use During Pregnancy". Drugs.com. Retrieved 2022-11-15.
- ↑
Tiotropium Bromide Media
- Spiriva
"Spiriva HandiHaler"-brand dry powder inhaler (open)
"The Top 300 of 2020". clincalc.com. Retrieved 2022-11-15.
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