Adderall
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| Combination of | |||
|---|---|---|---|
| Amphetamine aspartate monohydrate | 25% – stimulant (12.5% levo; 12.5% dextro) | ||
| Amphetamine sulfate | 25% – stimulant (12.5% levo; 12.5% dextro) | ||
| Dextroamphetamine saccharate | 25% – stimulant (0% levo; 25% dextro) | ||
| Dextroamphetamine sulfate | 25% – stimulant (0% levo; 25% dextro) | ||
| Clinical data | |||
| Trade names | Adderall, Adderall XR, others | ||
| Synonyms | Mixed amphetamine salts; MAS | ||
| AHFS/Drugs.com | Monograph | ||
| MedlinePlus | a601234 | ||
| License data | |||
| Dependence liability | Moderate[1][2] – high[3][4][5] | ||
| Routes of administration | Medical: Oral Recreational: Oral, insufflation, rectal, sublingual | ||
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| Pharmacokinetic data | |||
| Bioavailability | Oral: ~90%[7] | ||
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Amphetamine mixed salts (also known as amphetamine and dextroamphetamine mixed salts, amphetamine salt combo, or simply amphetamine salts) is a medication used to help attention-deficit hyperactivity disorder (ADHD) and narcolepsy.[8]
It is sold under the brand name Adderall. The drug contains a mixture of the salts of amphetamine and dextroamphetamine. Both of these salts act as stimulants. The drug helps people stay alert and concentrate on what they are doing. It is prescribed to people with ADHD because it helps them stay focused. In those people it can make them calmer. The downside of adderall is decreased appetite, alongside other side effects.
The sustained-release (or extended-release) formulation is sold under the brand name Adderall XR. This formulation is designed to provide therapeutic effect for longer and keep plasma concentrations of the drugs stable for longer. This is the same as taking two doses 4 hours apart.[9]
Key ingredients of Adderall (amphetamine)
Active ingredients
- Amphetamine aspartate
- Dextroamphetamine saccharate
- Amphetamine sulfate
- Dextroamphetamine sulfate
Inactive ingredients
- Saccharin sodium
- Colloidal silicon dioxide
- Microcrystalline cellulose
- Compressible sugar
- Corn starch
- Magnesium stearate
References
- ↑ Understanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function. Child and Adolescent Psychiatric Clinics of North America 17 (2) (April 2008). p. 459–74, xi. doi:10.1016/j.chc.2007.11.010.
- ↑ European guidelines on managing adverse effects of medication for ADHD. European Child & Adolescent Psychiatry 20 (1) (January 2011). p. 17–37. doi:10.1007/s00787-010-0140-6.
- ↑ Evaluation of risks associated with short- and long-term psychostimulant therapy for treatment of ADHD in children. Expert Opinion on Drug Safety 3 (2) (March 2004). p. 93–100. doi:10.1517/14740338.3.2.93.
- ↑ The potential for misuse and abuse of medications in ADHD: a review. Postgraduate Medicine 126 (5) (September 2014). p. 64–81. doi:10.3810/pgm.2014.09.2801.
- ↑ https://en.wikipedia.org/wiki/Special:BookSources/978-1-108-22874-9
- ↑ Ingersoll, John. Amphetamine, Methamphetamine, and Optical Isomers. Federal Register (7 July 1971)Bureau of Narcotics and Dangerous Drugs. Retrieved 27 November 2024.
- ↑ https://doi.org/10.1007%2F978-3-030-92392-1_104
- ↑ Schwartz A. Drowned in a Stream of Prescriptions. New York Times (2013-02-13).
- ↑ Medication Guide Adderall XRUS Food and Drug Administration (FDA). Retrieved 19 May 2013.
