Alcohol (drug)
| 175px | |||
| |||
| Clinical data | |||
|---|---|---|---|
| Pronunciation | /ˈɛθənɒl/ | ||
| Synonyms | Absolute alcohol; alcohol (USP); cologne spirit; drinking alcohol; ethanol (JAN); ethylic alcohol; EtOH; ethyl alcohol; ethyl hydrate; ethyl hydroxide; ethylol; grain alcohol; hydroxyethane; methylcarbinol | ||
| Pregnancy category |
| ||
| Dependence liability | Moderate[1] | ||
| Addiction liability | Moderate (10–15%)[2] | ||
| Routes of administration | Common: By mouth Uncommon: Suppository, inhalation, ophthalmic, insufflation, injection[3] | ||
| Drug class | Depressant; anxiolytic; analgesic; euphoriant; sedative; emetic; diuretic; general anesthetic | ||
| ATC code | |||
| Legal status | |||
| Legal status |
| ||
| Pharmacokinetic data | |||
| Bioavailability | 80%+[6][7] | ||
| Protein binding | Weakly or not at all[6][7] | ||
| Metabolism | Liver (90%):[4][5] • Alcohol dehydrogenase • MEOS (CYP2E1) | ||
| Metabolites | Acetaldehyde; acetic acid; acetyl-CoA; carbon dioxide; water; ethyl glucuronide; ethyl sulfate | ||
| Onset of action | Peak concentrations:[4][6] • Range: 30–90 minutes • Mean: 45–60 minutes • Fasting: 30 minutes | ||
| Elimination half-life | Constant-rate elimination at typical concentrations:[8][5][4] • Range: 10–34 mg/dL/hour • Mean: 15-18 mg/dL/hr At very high concentrations (t1/2): 4.0–4.5 hours[7][6] | ||
| Duration of action | 6–16 hours (amount of time that levels are detectable)[9] | ||
| Excretion | • Major: metabolism (into carbon dioxide and water)[6] • Minor: urine, breath, sweat (5–10%)[4][6] | ||
| Identifiers | |||
| CAS Number | |||
| PubChem CID | |||
| IUPHAR/BPS | |||
| DrugBank | |||
| ChemSpider | |||
| UNII | |||
| KEGG | |||
| ChEBI | |||
| ChEMBL | |||
| PDB ligand | |||
| E number | |||
| ECHA InfoCard | |||
| Chemical and physical data | |||
| Formula | C2H6O | ||
| Molar mass | 46.07 g·mol−1 | ||
| 3D model (JSmol) | |||
| Density | 0.7893 g/cm3 (at 20 °C)[10] | ||
| Melting point | −114.14 ± 0.03 °C (−173.45 ± 0.05 °F) [10] | ||
| Boiling point | 78.24 ± 0.09 °C (172.83 ± 0.16 °F) [10] | ||
| Solubility in water | Miscible mg/mL (20 °C) | ||
Expression error: Unexpected < operator.Expression error: Unexpected < operator.Expression error: Unexpected < operator.
Alcohol, is (an ingredient or) the active ingredient in alcoholic drinks such as beer, wine, and distilled spirits (hard liquor). Alcohol is sometimes called by its chemical name ethanol.[11]
Alcohol is a central nervous system (CNS) depressant. This means that alcohol lowers electrical activity of neurons in the brain.[12] This causes drunkenness.[13] Alcohol can also cause euphoria, decreased anxiety, sociability, sedation, and lowered cognitive, memory, motor, and sensory function.
Alcohol (drug) Media
- A group of merry, dancing invalids discarding their medicine Wellcome V0011166.jpg
A group of merry, dancing invalids discarding their medicines in favour of alcohol as a cure. Coloured aquatint by G. Hunt, 1827, after T. Lane.
Baby with fetal alcohol syndrome, showing some of the characteristic facial features.
- The Alcohol Flushing Response.png
Facial flushing. Before (left) and after (right) drinking alcohol. A 22-year-old East Asian man who is ALDH2 heterozygous showing the reaction.
- Deaths from alcohol and drug use disorders, OWID.svg
Deaths from alcohol and drug use disorders.
- Symptoms of BAC, 0.02% to 0.50% concentration.svg
Symptoms of varying BAC levels. Additional symptoms may occur.
- Pohmelye.jpg
One of the signs of a severe hangover is a headache
The 2010 DrugScience study ranking various illegal and legal drugs based on statements by drug-harm experts. Alcohol was rated to be the 4th most harmful drug to users, the drug most harmful to others, and the most harmful drug overall.
- Alcohol use disorders world map-Deaths per million persons-WHO2012.svgAlcohol use disorders deaths per million persons in 2012** 52*
- Boite de librax44.jpg
Chlordiazepoxide (trade name Librium) is the most commonly used benzodiazepine for alcohol detoxification.
- Number of deaths from substance use disorders, OWID.svg
Alcohol is the leading cause of direct deaths from drug overdoses.
Related pages
References
- ↑ WHO Expert Committee on Problems Related to Alcohol Consumption: second report. Geneva, Switzerland: World Health Organization. 2007. p. 23. ISBN 978-92-4-120944-1. Retrieved 3 March 2015.
...alcohol dependence (is) a substantial risk of regular heavy drinking...
- ↑ Vengeliene V, Bilbao A, Molander A, Spanagel R (May 2008). "Neuropharmacology of alcohol addiction". British Journal of Pharmacology. 154 (2): 299–315. doi:10.1038/bjp.2008.30. PMC 2442440. PMID 18311194.
(Compulsive alcohol use) occurs only in a limited proportion of about 10–15% of alcohol users....
- ↑ Gilman JM, Ramchandani VA, Crouss T, Hommer DW (January 2012). "Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns". Neuropsychopharmacology. 37 (2): 467–77. doi:10.1038/npp.2011.206. PMC 3242308. PMID 21956438.
- ↑ 4.0 4.1 4.2 4.3 Lua error in Module:Citation/CS1/Identifiers at line 630: attempt to index field 'known_free_doi_registrants_t' (a nil value).
- ↑ 5.0 5.1 Levine B (2003). Principles of Forensic Toxicology. Amer. Assoc. for Clinical Chemistry. pp. 161–. ISBN 978-1-890883-87-4.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Principles of Addiction: Comprehensive Addictive Behaviors and Disorders. Academic Press. 17 May 2013. pp. 162–. ISBN 978-0-12-398361-9.
- ↑ 7.0 7.1 7.2 Lua error in Module:Citation/CS1/Identifiers at line 630: attempt to index field 'known_free_doi_registrants_t' (a nil value).
- ↑ Becker CE (September 1970). "The clinical pharmacology of alcohol". California Medicine. 113 (3): 37–45. PMC 1501558. PMID 5457514.
- ↑ Iber FL (26 November 1990). Alcohol and Drug Abuse as Encountered in Office Practice. CRC Press. pp. 74–. ISBN 978-0-8493-0166-7.
- ↑ 10.0 10.1 10.2 Haynes, William M., ed. (2011). CRC Handbook of Chemistry and Physics (92nd ed.). Boca Raton, FL: CRC Press. p. 3.246. ISBN 1439855110.
- ↑ Lua error in Module:Citation/CS1/Identifiers at line 630: attempt to index field 'known_free_doi_registrants_t' (a nil value).
- ↑ Lua error in Module:Citation/CS1/Identifiers at line 630: attempt to index field 'known_free_doi_registrants_t' (a nil value).
- ↑ "10th Special Report to the U.S. Congress on Alcohol and Health: Highlights from Current Research" (PDF). National Institute of Health. National Institute on Alcohol Abuse and Alcoholism. June 2000. p. 134. Retrieved 21 October 2014.
The brain is a major target for the actions of alcohol, and heavy alcohol consumption has long been associated with brain damage. Studies clearly indicate that alcohol is neurotoxic, with direct effects on nerve cells. Chronic alcohol abusers are at additional risk for brain injury from related causes, such as poor nutrition, liver disease, and head trauma.
Further reading
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1988). Alcohol Drinking. International Agency for Research on Cancer.
Other websites
- "ETOH Database Search". hazelden.org.
- The National Institute on Alcohol Abuse and Alcoholism maintains a database of alcohol-related health effects. ETOH Archival Database (1972–2003) Alcohol and Alcohol Problems Science Database.
- "Harmful Interactions". National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- WHO fact sheet on alcohol
- ChEBI – biology related
- Kyoto Encyclopedia of Genes and Genomes signal transduction pathway: KEGG – human alcohol addiction