Appleton is a city in Outagamie (mostly), Calumet, and Winnebago counties in Wisconsin, United States.
It is near the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee.
Appleton is the county seat of Outagamie County. The population was 72,623 at the 2010 census.
There are three public high schools (Appleton East, Appleton North, and Appleton West) and two religious high schools (Roman Catholic Xavier High School and Fox Valley Lutheran High School). Several charter high schools also serve the children of Appleton.
Lawrence University has its main campus in Appleton.  Fox Valley Technical College is also in Appleton.