Dimethyltryptamine
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Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine (N,N-DMT), is a psychedelic drug from the tryptamine family that is found in nature in many plants and animals.[1][2][3][9] DMT is used as a recreational drug and for spiritual reasons.[10]
DMT works very quickly, has strong hallucinogenic effects, and works for only a few minutes. These reasons mean people in jobs such as businesspeople are known to use it.[11] DMT can be inhaled or injected and its effects are different with different amounts used or different ways of taking it. When inhaled or injected, the effects last about five to fifteen minutes. Effects can last three hours or more when swallowed with a monoamine oxidase inhibitor (MAOI), such as ayahuasca used by Amazonian tribes.[12] DMT causes effects that are hard to describe with words, such as very complex visual hallucinations (seeing things that are not there), changes to senses, ego death. DMT is not addictive but can cause issues for the heart.
Dimethyltryptamine Media
Ayahuasca preparation.
Free-base DMT powder extracted from Mimosa hostilis root bark (left); vape cartridge made with free-base DMT extract (right).
Dimethyltryptamine (DMT) crystals
DMT during various stages of purification
Biosynthetic pathway for N,N-dimethyltryptamine
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT). ACS Chem Neurosci 9 (10) (October 2018). p. 2344–2357. doi:10.1021/acschemneuro.8b00101.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Neuropharmacology of N,N-dimethyltryptamine. Brain Research Bulletin 126 (Pt 1) (September 2016). p. 74–88. doi:10.1016/j.brainresbull.2016.04.016.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Dimethyltryptamine: Endogenous Role and Therapeutic Potential. J Psychoactive Drugs 51 (4) (2019). p. 299–310. doi:10.1080/02791072.2019.1602291.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact. Pharmaceuticals (Basel) 13 (11) (October 2020). p. 334. doi:10.3390/ph13110334.
- ↑ Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial (in pt-BR) (2023-07-24)Diário Oficial da União. Retrieved 2023-08-27.
- ↑ Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. Psychopharmacology (Berl) 239 (6) (June 2022). p. 1749–1763. doi:10.1007/s00213-022-06065-0.
- ↑ Untersuchungen zur Trifluoracetylierung der Methylderivate von Tryptamin und Serotonin mit verschiedenen Derivatisierungsreagentien: Synthesen, Spektroskopie sowie analytische Trennungen mittels Kapillar-GC. Zeitschrift für Naturforschung B 54 (3) (1999). p. 397–414. doi:10.1515/znb-1999-0319.
- ↑ Constituents of the bark of Virola sebifera. Planta Medica 17 (2) (May 1969). p. 184–188. doi:10.1055/s-0028-1099844.
- ↑ Dimethyltryptamine (in en). PubChemU.S. National Library of Medicine. Retrieved 2025-05-22.
- ↑ Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca. Journal of Ethnopharmacology 10 (2) (April 1984). p. 195–223. doi:10.1016/0378-8741(84)90003-5.
- ↑ Emerging drugs of abuse. The Medical Clinics of North America 89 (6) (November 2005). p. 1259–1276. doi:10.1016/j.mcna.2005.06.008. OCLC 610327022.
- ↑ Sex, Drugs, Einstein, and Elves: Sushi, Psychedelics, Parallel Universes, and the Quest for Transcendence (2005)Smart Publications. ISBN 978-1-890572-17-4.
