Lymphoma

Lymphoma is a cancer of the lymphatic system. There are many types of lymphoma, including Hodgkin's lymphoma, non-Hodgkin lymphoma, primary central nervous system lymphoma, the B-cell lymphoma, and the hepatosplenic lymphoma.

Symptoms

• Larger-than-normal lymph nodes
• Sweating at night
• Fevers that happen often or do not get better
• Weight loss
• Fatigue (feeling tired)
• Enlarged spleen
• Enlarged liver

Treatment

Chemotherapy is often used for both Hodgkin's lymphoma and non-Hodgkin lymphoma. Radiotherapy may also be used.

Lymphoma Media

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  The lymph nodes where lymphoma most commonly develops

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  Lymphoma and lymphatic system

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  An initial evaluation of a suspected lymphoma is to make a "touch prep" wherein a glass slide is lightly pressed against excised lymphoid tissue, and subsequently stained (usually H&E stain) for evaluation under light microscopy.

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  Lymph node with mantle cell lymphoma (low-power view, H&E)

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  DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. Colors indicate levels of expression; green indicates genes that are underexpressed in lymphoma cells (as compared to normal cells), whereas red indicates genes that are overexpressed in lymphoma cells.

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  Diagram showing common sites where lymphoma spreads

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  Deaths from lymphomas and multiple myeloma per million persons in 2012

  *     0–13     14–18     19–22     23–28     29–34     35–42     43–57     58–88     89–121     122–184
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  Thomas Hodgkin

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  Mantle cell lymphoma: Notice the irregular nuclear contours of the medium-sized lymphoma cells and the presence of a pink histiocyte. By immunohistochemistry, the lymphoma cells expressed CD20, CD5, and Cyclin D1 (high-power view, H&E)

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  Hodgkin lymphoma, nodular lymphocyte predominant (low-power view): Notice the nodular architecture and the areas of "mottling". (H&E)