mTOR
mTOR is a protein, an enzyme which regulates cell growth, cell division, cell movement, cell survival, protein synthesis, autophagy, and transcription.[1] It is a protein that in humans is encoded by the MTOR gene.[2][3]
It has been given various names. It was originally called the 'mammalian target of rapamycin', but is also known as the 'mechanistic target of rapamycin' and 'FK506-binding protein 12-rapamycin-associated protein 1' (FRAP1).
The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain.[4]
MTOR Media
References
- ↑ Hay, Nissim. Upstream and downstream of mTOR. Genes & Development 18 (16) (2004). p. 1926–45. doi:10.1101/gad.1212704.
- ↑ Brown, Eric J.. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369 (6483) (1994). p. 756–8. doi:10.1038/369756a0.
- ↑ Moore, Paul A.. Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization. Genomics 33 (2) (1996). p. 331–2. doi:10.1006/geno.1996.0206.
- ↑ Betz, Charles. Where is mTOR and what is it doing there?. Journal of Cell Biology 203 (4) (2013). p. 563–74. doi:10.1083/jcb.201306041.