Progesterone

	Progesterone
	Systematic (IUPAC) name
	Pregn-4-ene-3,20-dione
	Identifiers
CAS number	57-83-0
ATC code	G03DA04
PubChem	5994
DrugBank	DB00396
ChemSpider	5773
	Chemical data
Formula	C21H30Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxO2Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox
Mol. mass	314.46
SMILES	eMolecules & PubChem
Synonyms	4-pregnene-3,20-dione
	Physical data
Melt. point	126 °C (259 °F)
Spec. rot	[α]D
	Pharmacokinetic data
Bioavailability	prolonged absorption, half-life approx 25-50 hours
Protein binding	96%-99%
Metabolism	hepatic to pregnanediols and pregnanolones
Half life	34.8-55.13 hours
Excretion	renal
	Therapeutic considerations
Pregnancy cat.	B (USA)
Legal status
Routes	oral, implant, transdermal

Progesterone is a steroid hormone. In animals, it is made from cholesterol. It is the base for making certain estrogens and androgens. In animals, it is produced by their body mainly during the second half of the menstrual cycle. During pregnancy it is produced in higher quantities. Willard Myron Allen co-discovered progesterone with his anatomy professor George Washington Corner at the University of Rochester Medical School in 1933 year. Allen discovered temperature needed to melt it and its weight. He also gave it the name Progesterone based on Progestational Steroidal ketone.^[1] In one plant, Juglans regia, progesterone has been found.^[2] Also progesterone-like steroids are found in Dioscorea mexicana.^[3] Progesterone level is low in children and postmenopausal women.^[4]

References

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[1] ttp://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=R2dc47m048bxLF2j9vg9nZGkV4LPQ9X4PTkhCqCVdsC7dJrhTPPm!1612949135!181195629!8091!-1?sid=WKPTLP:landingpage&an=00007611-197010000-00012

[2] ttp://pubs.acs.org/doi/abs/10.1021/np9007415

[3] ttp://buynaturalprogesterone.co.uk/

[4] ttp://cclnprod.cc.nih.gov/dlm/testguide.nsf/Index/CB26894E1EB28DEF85256BA5005B000E?OpenDocument

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Progesterone
Systematic (IUPAC) name
Pregn-4-ene-3,20-dione
Identifiers
CAS number	57-83-0
ATC code	G03DA04
PubChem	5994
DrugBank	DB00396
ChemSpider	5773
Chemical data
Formula	C₂₁H₃₀Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox O₂Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox Template:OrganicBox
Mol. mass	314.46
SMILES	eMolecules & PubChem
Synonyms	4-pregnene-3,20-dione
Physical data
Melt. point	126 °C (259 °F)
Spec. rot	[α]_D
Pharmacokinetic data
Bioavailability	prolonged absorption, half-life approx 25-50 hours
Protein binding	96%-99%
Metabolism	hepatic to pregnanediols and pregnanolones
Half life	34.8-55.13 hours
Excretion	renal
Therapeutic considerations
Pregnancy cat.	B (USA)
Legal status
Routes	oral, implant, transdermal