Thiamine
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 Skeletal formula and ball-and-stick model of the cation in thiamine | |
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| Pronunciation | /ˈθaɪ.əmɪn/ THY-ə-min |
| Synonyms | Vitamin B1, aneurine, thiamin |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | by mouth, IV, IM[1] |
| Drug class | vitamin |
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| Bioavailability | 3.7% to 5.3% Template:Medical citation needed |
| Elimination half-life | 1.8d[2][better source needed] |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C12H17N4OS+ |
| Molar mass | 265.36 g·mol−1 |
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Thiamine (or thiamin) is vitamin B1. It is a water-soluble vitamin of the B complex. Its phosphate derivatives take part in many cellular processes. Thiamine pyrophosphate (TPP) is a coenzyme in the catabolism of sugars and amino acids.
also it can be found in Food and Manufactured Dietary supplements also in Medications[1][3] Foods that provide Thiamine include whole grains, Legume[1]
Lack of thiamine causes beriberi.
Thiamine Media
Thiamine monophosphate (ThMP)
Thiamine triphosphate (ThTP)
The biosynthetic step catalysed by phosphomethylpyrimidine synthase, part of the pathway to the vitamin thiamine. Coloured portions show which parts of the substrate are incorporated in the product
Thiamine biosynthesis from 1-deoxy-D-xylulose-5-phosphate, incorporating glycine imine and the pyrimidine ring as its pyrophosphate
A 3D representation of the TPP riboswitch with thiamine bound
The synthesis of thiamine (vitamin B1) as originally reported by R. R.Williams and J. K. Cline in 1936 (doi=10.1021/ja01299a505) and reviewed in doi=10.1042/BSR20171148
Diamine used in the manufacture of thiamine
- TakakiKanehiro
Christiaan Eijkman (1858-1930)
- Portrait of Gerrit Grijns, head and shoulders General Collections*Keywords: Gerrit Grijns
References
- ↑ 1.0 1.1 1.2 "Thiamin Fact Sheets for Health Professionals". Office of Dietary Supplements. 11 February 2016. Archived from the original on 30 December 2016. Retrieved 30 December 2016.
- ↑ Royer-Morrot MJ, Zhiri A, Paille F, Royer RJ (1992). "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of Clinical Pharmacology. 42 (2): 219–22. doi:10.1007/BF00278489. PMID 1618256. S2CID 19924442.
- ↑ "Thiamine: MedlinePlus Drug Information". medlineplus.gov. Retrieved 30 April 2018.