Thiamine

Thiamine

File:Thiamin.svg
File:Thiamine cation 3D ball.png Skeletal formula and ball-and-stick model of the cation in thiamine
Clinical data
Pronunciation	/ˈθaɪ.əmɪn/ ( listen) THY-ə-min
Synonyms	Vitamin B1, aneurine, thiamin
AHFS/Drugs.com	Monograph
License data	US DailyMed: Thiamine US FDA: Thiamine
Routes of administration	by mouth, IV, IM
Drug class	vitamin
ATC code	cation: A11DA01 (WHO)
Legal status
Legal status	US: OTC
Pharmacokinetic data
Bioavailability	3.7% to 5.3% Template:Medical citation needed
Elimination half-life	1.8d
Identifiers
IUPAC name 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol
CAS Number	cation: 70-16-6 7pxY 67-03-8 (Cl-.HCl) Cl- salt: 59-43-8  7pxY
PubChem CID	cation: 1130
PubChem SID	Cl- salt: 6042
DrugBank	cation: DB00152
ChemSpider	cation: 1098
UNII	cation: 4ABT0J945J Cl- salt: X66NSO3N35 7pxY
KEGG	cation: C00378
ChEBI	cation: CHEBI:18385
ChEMBL	cation: ChEMBL1547
E number
ECHA InfoCard
Chemical and physical data
Formula	C12H17N4OS+
Molar mass	265.36 g·mol−1
3D model (JSmol)	cation: Interactive image
SMILES cation: Cc2ncc(C[n+]1csc(CCO)c1C)c(N)n2
InChI cation: InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 7pxY Key:JZRWCGZRTZMZEH-UHFFFAOYSA-N

Thiamine (or thiamin) is vitamin B₁. It is a water-soluble vitamin of the B complex. Its phosphate derivatives take part in many cellular processes. Thiamine pyrophosphate (TPP) is a coenzyme in the catabolism of sugars and amino acids.

also it can be found in Food and Manufactured Dietary supplements also in Medications Foods that provide Thiamine include whole grains, Legume

Lack of thiamine causes beriberi.

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Thiamine Media

• 

  Thiamine monophosphate (ThMP)

• Thiamine triphosphate coloured.svg

  Thiamine triphosphate (ThTP)

• Pyrimidine biosynthesis.svg

  The biosynthetic step catalysed by phosphomethylpyrimidine synthase, part of the pathway to the vitamin thiamine. Coloured portions show which parts of the substrate are incorporated in the product

• Thiamine biosynthesis.svg

  Thiamine biosynthesis from 1-deoxy-D-xylulose-5-phosphate, incorporating glycine imine and the pyrimidine ring as its pyrophosphate

• TPP riboswitch pdb-2hoj.png

  A 3D representation of the TPP riboswitch with thiamine bound

• Thiamine synthesis.svg

  The synthesis of thiamine (vitamin B1) as originally reported by R. R.Williams and J. K. Cline in 1936 (doi=10.1021/ja01299a505) and reviewed in doi=10.1042/BSR20171148

• Grewe diamine.svg

  Diamine used in the manufacture of thiamine

• Takaki Kanehiro.jpg

  TakakiKanehiro

• Eijkman.jpg

  Christiaan Eijkman (1858-1930)

• Portrait of Gerrit Grijns Wellcome M0010254.jpg

  • Portrait of Gerrit Grijns, head and shoulders General Collections*Keywords: Gerrit Grijns