kidzsearch.com > wiki   Explore:web images videos games  

Oxycodone




KidzSearch Safe Wikipedia for Kids.
Jump to: navigation, search
Oxycodone
Systematic (IUPAC) name
(5R,9R,13S,14S)-4,5α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Identifiers
CAS number 76-42-6
ATC code N02AA05
N02AA55 (in combinations)
PubChem 5284603
DrugBank DB00497
ChemSpider 4447649
Chemical data
Formula C18H21NO4 
Mol. mass 315.364 g/mol
SMILES eMolecules & PubChem
Synonyms dihydrohydroxycodeinone, 14-hydroxydihydrocodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine[1]
Physical data
Solubility in water HCl: 166 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability 60-87%[2]
Protein binding 45%[2]
Metabolism Hepatic: primarily CYP3A and to a lesser extent, CYP2D6 to oxymorphone[2]
Half life 2-4 hours.[2]
Excretion Urine (83%)[2]
Therapeutic considerations
Pregnancy cat.

C(AU) B; D (US; near term)

Legal status

Controlled (S8)(AU) Schedule I(CA) ?(UK) Schedule II(US)

Dependence Liability Moderate–High
Routes oral, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural[3]

Oxycodone is a synthetic opioid. It is used as an analgesic, to relieve pain. Its structure is similar to codeine. As a painkiller, it is usually marketed in drugs that combine it with paracetamol, aspirin or other NSAIDs. In some forms, the oxycodone can be extracted very easily. Some people use this as an illegal drug. Like with most other opioids, there is a high risk of addiction.

Sources

  1. O'Neil, Maryadele J., ed. (2006). The Merck index (14 ed.). Whitehouse Station, NJ: Merck & Co.. ISBN 978-0-911910-00-1 . 
  2. 2.0 2.1 2.2 2.3 2.4 "Roxicodone, OxyContin (oxycodone) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. http://reference.medscape.com/drug/roxicodone-oxycontin-oxycodone-343321#showall. Retrieved 8 April 2014. 
  3. Kalso E (2005). "Oxycodone". Journal of Pain and Symptom Management 29 (5S): S47–S56. doi:10.1016/j.jpainsymman.2005.01.010 . PMID 15907646 .