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List of epidemics



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This article is a list of major pandemics and epidemics caused by infectious diseases in human history. Events in boldface are ongoing.

Epidemics with at least 1 million deaths
Rank Epidemics/pandemics Date Location Death toll
1 Black Death 1346–1353 Europe, Asia and North Africa 75–200 million
2 Spanish flu 1918–1920 Worldwide 17–100 million
3 Plague of Justinian 541–542 Europe and West Asia 15–100 million
4 HIV/AIDS pandemic 1981–present Worldwide 35 million+ (2020)
5 Third plague pandemic 1855–1960 Worldwide 12–15 million
6 Cocoliztli Epidemic of 1545–1548 1545–1548 Mexico 5–15 million
7 Antonine Plague 165–180 Roman Empire 5–10 million
8 1520 Mexico smallpox epidemic 1519–1520 Mexico 5–8 million
9 COVID-19 pandemic 2019–present Worldwide 4 million+ (July 2021)
10 Asian flu 1957–1958 Worldwide 1–4 million
Hong Kong flu 1968–1969 Worldwide
11 1918–1922 Russia typhus epidemic 1918–1922 Russia 2–3 million
14 735–737 Japanese smallpox epidemic 735–737 Japan 2 million
1772–1773 Persian Plague 1772–1773 Persia 2 million
16 Naples Plague 1656–1658 Italy 1.25 million
17 Third cholera pandemic 1846–1860 Worldwide 1 million+
18 1629–1631 Italian plague 1629–1631 Italy 1 million
1889–1890 flu pandemic 1889–1890 Worldwide 1 million

Worldwide Pandemics

Regional

Asia

Central and South America

Europe

Egypt & North Africa

North America

References

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