List of epidemics

This article is a list of major pandemics and epidemics caused by infectious diseases in human history. Events in boldface are ongoing.

Epidemics with at least 1 million deaths
Rank Epidemics/pandemics Date Location Death toll
1 Black Death 1346–1353 Europe, Asia and North Africa 75–200 million
2 Spanish flu 1918–1920 Worldwide 17–100 million
3 Plague of Justinian 541–542 Europe and West Asia 15–100 million
4 HIV/AIDS pandemic 1981–present Worldwide 35 million+ (2020)
5 Third plague pandemic 1855–1960 Worldwide 12–15 million
6 Cocoliztli Epidemic of 1545–1548 1545–1548 Mexico 5–15 million
7 Antonine Plague 165–180 Roman Empire 5–10 million
8 1520 Mexico smallpox epidemic 1519–1520 Mexico 5–8 million
9 COVID-19 pandemic 2019–present Worldwide 4 million+ (July 2021)
10 Asian flu 1957–1958 Worldwide 1–4 million
Hong Kong flu 1968–1969 Worldwide
11 1918–1922 Russia typhus epidemic 1918–1922 Russia 2–3 million
14 735–737 Japanese smallpox epidemic 735–737 Japan 2 million
1772–1773 Persian Plague 1772–1773 Persia 2 million
16 Naples Plague 1656–1658 Italy 1.25 million
17 Third cholera pandemic 1846–1860 Worldwide 1 million+
18 1629–1631 Italian plague 1629–1631 Italy 1 million
1889–1890 flu pandemic 1889–1890 Worldwide 1 million

Worldwide Pandemics

Regional

Asia

Central and South America

Europe

Egypt & North Africa

North America

References

  • Kuhnke, Laverne. Lives at Risk: Public Health in Nineteenth-Century Egypt. Berkeley: University of California Press, c1990.
  • Gallagher, Nancy. Egypt's Other Wars: Epidemics and the Politics of Public Health. Syracuse University Press, c1990. Published by the American University in Cairo Press. ISBN 977-424-295-5
  • Kinch, Michael. Between Hope and Fear: A History of Vaccines and Human Immunity. New York: Pegasus Books, 2018. ISBN 9781681777511
  • Rosen, William, Justinian's Flea: Plague, Empire and the Birth of Europe, New York: Penguin Random House, 2008 ISBN 9780143113812
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Morens, David M.. Pandemic influenza: certain uncertainties. Reviews in medical virology 21 (5) (2011-9). p. 262–284. doi:10.1002/rmv.689.
  2. Justinian's Flea -. www.justiniansflea.com. Retrieved 2020-08-18.
  3. Three Books on the Black Death | The Heritage Portal. www.theheritageportal.co.za. Retrieved 2020-08-18.
  4. Raoult, Didier. The history of epidemic typhus (in en). Historical Aspects of Infectious Diseases, Part I. Infectious Disease Clinics of North America 18 (1) (2004-03-01). p. 127–140. doi:10.1016/S0891-5520(03)00093-X.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 S, Peter M.. A severe pandemic is not overdue - it's not when but if (in en). CIDRAP. Retrieved 2020-08-18.
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Cholera - Cholera through history (in en). Encyclopedia Britannica. Retrieved 2020-08-20.
  7. Rolleston, J. D.. The Smallpox Pandemic of 1870–1874: President's Address (in en). Proceedings of the Royal Society of Medicine 27 (2) (1933-12). p. 177–192. doi:10.1177/003591573302700245.
  8. The Great Influenza (in en). Wikipedia (2020-06-27).
  9. June 05, Content Source: HIV govDate last updated:. What Are HIV and AIDS? (in en). HIV.gov (2020-06-05). Retrieved 2021-01-15.
  10. Severe Acute Respiratory Syndrome (SARS) (in en). www.who.int. Retrieved 2020-08-18.
  11. CDC. 2009 H1N1 Pandemic (in en-us). Centers for Disease Control and Prevention (2019-06-11). Retrieved 2021-02-06.
  12. Home (in en). Johns Hopkins Coronavirus Resource Center. Retrieved 2021-02-06.
  13. Coronavirus Update (Live): 106,308,198 Cases and 2,318,294 Deaths from COVID-19 Virus Pandemic - Worldometer (in en). www.worldometers.info. Retrieved 2021-02-06.
  14. what's the story?. Diphtheria. Retrieved 2020-08-18.
  15. Between Hope and Fear. pegasusbooks.com. Retrieved 2020-08-18.
  16. Timeline | History of Vaccines (in en). www.historyofvaccines.org. Retrieved 2020-08-20.
  17. 17.00 17.01 17.02 17.03 17.04 17.05 17.06 17.07 17.08 17.09 17.10 Disease & Death in Early America: Tully Area Historical Society. www.tullyhistoricalsociety.org. Retrieved 2020-08-20.
  18. Morens, David M.. The Past Is Never Dead—Measles Epidemic, Boston, Massachusetts, 1713. Emerging Infectious Diseases 21 (7) (2015-7). p. 1257–1260. doi:10.3201/eid2107.150397.
  19. NYCdata: Cholera Outbreak (1849). www.baruch.cuny.edu. Retrieved 2020-08-18.
  20. Watson, Denise. The Yellow Fever outbreak wiped out 3,000 in Hampton Roads. On Wednesday, they'll be remembered.. pilotonline.com. Retrieved 2020-08-18.
  21. Editors, History com. First victim of Memphis yellow fever epidemic dies (in en). HISTORY. Retrieved 2020-08-20.
  22. THE TYPHOID EPIDEMIC AT BUTLER, PA. (in en). Journal of the American Medical Association XLI (25) (1903-12-19). p. 1542–1542. doi:10.1001/jama.1903.02490440032004.

Related pages