2000 (MM) was a leap year that started on a Saturday in the Christian or Common Era, according to the Gregorian calendar. It was the last year of the 2nd millennium and the 20th century but the 1st of the 2000s decade. Y2K passed without the serious computer failures. The year 2000 was also the first century leap year since 1600.
- January 3–10 – Israel and Syria hold inconclusive peace talks.
- January 4 – Alan Greenspan is nominated for a fourth term as U.S. Federal Reserve Chairman.
- January 5–8 – The 2000 al-Qaeda Summit of several high-level al-Qaeda members (including 2 9/11 American Airlines hijackers) is held in Kuala Lumpur, Malaysia.
- January 6 – The last natural pyrenean ibex is found dead apparently killed by a falling tree.
- January 10 – America Online announces an agreement to purchase Time Warner for $162 billion (the largest-ever corporate merger).
- January 11 – The armed wing of the Islamic Salvation Front concludes its negotiations with the government for an amnesty and disbands in Algeria
- January 11 – The trawler Solway Harvester sinks off the Isle of Man.
- January 12 – 9/11 hijackers Mohammed Atta and Ziad Jarrah read their wills in the Martyrdom Video.
- January 14 – A United Nations tribunal sentences 5 Bosnian Croats to up to 25 years in prison for the 1993 killing of over 100 Bosnian Muslims in a Bosnian village.
- January 14 – The Dow Jones Industrial Average closes at 11,722.98 (at the peak of the Dot-com bubble).
- January 16 – In Sacramento, California, a commercial truck carrying evaporated milk is driven into the State Capitol building, killing the driver.
- January 18 – The Tagish Lake meteorite hits the Earth.
- January 24 – God's Army, a Karen militia group led by twins Johnny and Luther Htoo, takes 700 hostages at a Thai hospital near the Burmese border.
- January 26 – The rap-metal band Rage Against the Machine plays in front of Wall Street, prompting an early closing of trading due to the crowds.
- January 30 – Super Bowl XXXIV: The St. Louis Rams win the NFL Championship for the first time since 1951, defeating the Tennessee Titans 23–16.
- January 30 – Kenya Airways Flight 431 crashes off the coast of Côte d'Ivoire into the Atlantic Ocean, killing 169.
- January 31 – Alaska Airlines Flight 261 crashes off the California coast into the Pacific Ocean, killing 88.
- January 31 – Dr. Harold Shipman is found guilty of murdering 15 patients between 1995 and 1998. He is sentenced to life imprisonment.
- April 3 – United States v. Microsoft: Microsoft is ruled to have violated United States antitrust laws by keeping "an oppressive thumb" on its competitors.
- April 16 – Sultan Hisamuddin Alam Shah, Sultan of Selangor, dies after a reign of 55 years. He was the longest-reigning monarch in the world since the death of Prince Franz Joseph II of Liechtenstein.
- April 17 – Tuanku Syed Sirajuddin becomes Raja of Perlis.
- April 22 – Brazil officially celebrates its 500th anniversary, with protests, especially from native and black populations.
- April 22 – In a predawn raid, federal agents seize 6-year old Elián González from his relatives' home in Miami, Florida and fly him to his Cuban father in Washington, DC, ending one of the most publicized custody battles in U.S. history.
- April 25 – The State of Vermont passes HB847, legalizing civil unions for same-sex couples.
- April 28 – Richard Baumhammers begins a 2-hour racially motivated shooting spree in Pittsburgh, Pennsylvania, leaving 5 dead and 1 paralyzed.
- July 2 – France beats Italy 2–1 to win Euro 2000 with a golden goal.
- July 2 – Vicente Fox is elected President of Mexico, as candidate of the rightist PAN (National Action Party), ending 71 years of PRI (Institutional Revolutionary Party) rule.
- July 10 – In southern Nigeria, a leaking petroleum pipeline explodes, killing about 250 villagers who were scavenging gasoline.
- July 10 – Bashar al-Assad is confirmed as Syria's leader in a national referendum.
- July 11–25 – Israel's prime minister Ehud Barak and PLO head Yasser Arafat meet at Camp David, but fail to reach an agreement.
- July 14 – A powerful solar flare, later named the Bastille Day event, causes a geomagnetic storm on Earth.
- July 18 – Alex Salmond resigns as the leader of the Scottish National Party.
- July 18 – Sussex police launch a murder investigation after the body of a girl found near Pulborough is confirmed to be that of Sarah Payne, who was reported missing on July 1.
- July 21–23 – 26th G8 summit; issues include AIDS, the 'digital divide', and halving world poverty by 2015.
- July 22 – News of the World urges its readers to sign a petition for Sarah's Law, new legislation in response to the murder of Sarah Payne, which would give parents the right to know whether a convicted paedophile was living in their area.
- July 25 – Air France Flight 4590, a Concorde aircraft, crashes into a hotel in Gonesse just after takeoff from Paris, killing all 109 aboard and 4 in the hotel.
- July 30 – Venezuela's president Hugo Chávez is reelected with 59% of the vote.
- July 31 – August 3 – The Republican National Convention in Philadelphia, Pennsylvania nominates George W. Bush for U.S. President and Dick Cheney for Vice President.
- September 5 – Tuvalu joins the United Nations.
- September 5 – The Haverstraw-Ossining Ferry makes its maiden voyage.
- September 6 – In Paragould, Arkansas, Breanna Lynn Bartlett-Stewart is stillborn to Scott Stewart and Lisa Bartlett. Breanna Lynn's stillbirth is notable for being the first stillbirth to be resolved by means of the Kleihauer-Betke test.
- September 6 – The last wholly Swedish-owned arms manufacturer, Bofors, is sold to American arms manufacturer United Defense.
- September 6–8 – World leaders attend the Millennium Summit at UN Headquarters.
- September 7–14 – The UK fuel protests take place, with refineries blockaded, and supply to the country's network of petrol stations halted.
- September 8 – Albania officially joins the World Trade Organization.
- September 14 – Microsoft releases Windows ME.
- September 15 – October 1 – The 2000 Summer Olympics are held in Sydney, Australia.
- September 16 – Ukrainian journalist Georgiy Gongadze is last seen alive; this day is taken as the commemoration date of his death.
- September 16 – Peru's president Alberto Fujimori calls for new elections in which he will not run.
- September 26 – The Greek ferry Express Samina sinks off the coast of the island of Paros; 80 out of more than 500 passengers die in one of Greece's worst sea disasters.
- September 26 – Anti-globalization protests in Prague (some 15,000 protesters) turn violent during the IMF and World Bank summits.
- September 28 – Israeli opposition leader Ariel Sharon visits the Temple Mount, protected by a several-hundred-strong Israeli police force. Palestinian riots erupt, leading to a full-fledged armed uprising (called the Al-Aqsa Intifada by sympathizers and the Oslo War by opponents).
- September 29 – The Long Kesh prison in Northern Ireland is closed.
- October 1 – The 2000 Summer Olympics close in Sydney, Australia.
- October 5 – President Slobodan Milošević leaves office after widespread demonstrations throughout Serbia.
- October 6 – The last Mini is produced in Longbridge.
- October 11 – 250 million gallons of coal sludge spill in Martin County, Kentucky (considered a greater environmental disaster than the Exxon Valdez oil spill).
- October 12 – In Aden, Yemen, the USS Cole is badly damaged by two Al-Qaeda suicide bombers, who place a small boat laden with explosives alongside the United States Navy destroyer, killing 17 crew members and wounding at least 39.
- October 21 – Fifteen Arab leaders convene in Cairo, Egypt, for their first summit in 4 years; the Libyan delegation walks out, angry over signs the summit will stop short of calling for breaking ties with Israel.
- October 22 – The Mainichi Shinbun newspaper exposes Japanese archeologist Shinichi Fujimura as a fraud; Japanese archaeologists had based their treatises on his findings.
- October 23 – Madeleine Albright holds talks with North Korean dictator Kim Jong Il.
- October 26 – Pakistani authorities announce that their police have found an apparently ancient mummy of a Persian princess in the province of Balochistan. Iran, Pakistan and the Taliban all claim the mummy until Pakistan announces it is a forgery on April 17, 2001.
- October 27 – Pacific Islands Forum (PIF).
- October 30 – This is the final date during which there is no human presence in space; on October 31, Soyuz TM-31 launches, carrying the first resident crew to the International Space Station. The ISS has been continuously crewed since.
- October 31 – Singapore Airlines Flight 006 collides with construction equipment in the Chiang Kai Shek International Airport, resulting in 83 deaths.
- November – Iraq disarmament crisis: Iraq rejects new U.N. Security Council weapons inspections proposals.
- November 2 – The first resident crew enters the International Space Station.
- November 3 – Widespread flooding occurs throughout England and Wales after days of heavy rain.
- November 7 – United States presidential election, 2000: Republican candidate Texas Governor George W. Bush defeats Democratic Vice President Al Gore in the closest election in history, but the final outcome is not known for over a month because of disputed votes in Florida.
- November 7 – In London, a criminal gang raids the Millennium Dome to steal The Millennium Star diamond, but police surveillance catches them in the act.
- November 7 – Hillary Rodham Clinton is elected to the United States Senate, becoming the first First Lady of the United States to win public office.
- November 11 – Kaprun disaster, Austria: A cable car fire in an Alpine tunnel kills 155 skiers and snowboarders.
- November 15 – A new Indian state called Jharkhand is formed, carving out the South Chhota Nagpur area from Bihar in India.
- November 16 – Bill Clinton becomes the first sitting U.S. President to visit Vietnam.
- November 17 – A catastrophic landslide in Log pod Mangartom, Slovenia, kills 7, and causes millions of SIT of damage. It is one of the worst catastrophes in Slovenia in the past 100 years.
- November 17 – Alberto Fujimori is removed from office as president of Peru.
- November 25 – The Rugby League World Cup in England is ended, with Australia winning 40–12 over the New Zealand Kiwis.
- November 27 – Jean Chrétien is re-elected as Prime Minister of Canada, as the Liberal Party increases its majority in the House of Commons.
- November 28 – Ukrainian politician Oleksander Moroz touches off the Cassette Scandal by publicly accusing President Leonid Kuchma of involvement in the murder of journalist Georgiy Gongadze.
- December 1 – Vicente Fox takes office as President of Mexico.
- December 13 – Bush v. Gore: The U.S. Supreme Court stops the Florida presidential recount, effectively giving the state, and the Presidency, to George W. Bush.
- December 13 – The Texas 7 escape from their prison unit in Kenedy, Texas, and start a crime spree.
- December 15 – The third and final reactor at the Chernobyl Nuclear Power Plant is shut down and the station is shut down completely.
- December 24 – The Texas 7 rob a sports store in Irving, Texas; police officer Aubrey Hawkins is shot dead.
- December 24 – Christmas Eve 2000 Indonesia bombings: 18 people are killed in multiple Islamist bomb attacks on churches across Indonesia.
- December 25 – A shopping center fire at Luoyang, Henan, China kills 309.
- December 28 – U.S. retail giant Montgomery Ward announces it is going out of business after 128 years.
- December 30 – Rizal Day bombings: A series of bombs explode in various places in Metro Manila, Philippines, within a span of a few hours, killing 22 and injuring about 100.
- December 31 – The Millennium Dome closes its doors one year to the day of its opening.
- February 5 – Claude Autant-Lara, French movie director (b. 1901)
- February 5 – Ward Cornell, Canadian radio/TV broadcaster & educator (b. 1924)
- February 7 – Doug Henning, Canadian magician (b. 1947)
- February 7 – Big Pun, American rapper (b. 1971)
- February 9 – Beau Jack, American boxer (b. 1921)
- February 10 – Jim Varney, American actor noted for his character, Ernest P. Worrell. (b. 1949)
- February 12 – Tom Landry, American football coach (b. 1924)
- February 12 – Charles M. Schulz, American comic strip artist (Peanuts) (b. 1922)
- February 13 – Anders Aalborg, Canadian politician (b. 1914)
- February 19 – Friedensreich Hundertwasser, artist (b. 1928)
- February 23 – Sir Stanley Matthews, English footballer (b. 1915)
- February 23 – Ofra Haza, Israeli singer (b. 1957)
- April 3 – Terence McKenna, Writer, Philosopher, Ethnobotanist and Shaman (b. 1946)
- April 4 – Derek Allhusen, British equestrian (b. 1914)
- April 5 – Lee Petty, American race car driver (b. 1914)
- April 6 – Habib Bourguiba, Tunisian politician, 1st President of Tunisia (b. 1903)
- April 11 – Diana Darvey, British actress, singer and dancer (b. 1945)
- April 14 – Phil Katz, American computer programmer (b. 1962)
- April 15 – Edward Gorey, American writer and illustrator (b. 1925)
- April 25 – David Merrick, American stage producer (b. 1911)
- April 29 – Phạm Văn Đồng, Vietnamese politician, Prime Minister of Vietnam (b. 1906)
- May 1 – Steve Reeves, American actor and bodybuilder (b. 1926)
- May 3 – John Cardinal O'Connor, Archbishop of New York (b. 1920)
- May 7 – Douglas Fairbanks, Jr., American actor (b. 1909)
- May 10 – Craig Stevens, American actor (b. 1918)
- May 11 – René Muñoz, Cuban actor, screenwriter of telenovelas and the cinema of Mexico (b. 1938)
- May 13 – Tomomi Tsuruta, Former Japanese professional wrestler, better known as Jumbo Tsuruta (b. 1951)
- May 14 – Keizō Obuchi, Prime Minister of Japan (b. 1937)
- May 20 – Edward Bernds, American director (b. 1905)
- May 21 – Dame Barbara Cartland, English novelist (b. 1901)
- May 21 – Sir John Gielgud, English actor (b. 1904)
- May 25 – Francis Lederer, American actor (b. 1899)
- May 27 – Maurice Richard, Canadian hockey player (b. 1921)
- May 27 – Kazimierz Leski, Polish engineer, fighter pilot, and Home Army's intelligence and counter-intelligence officer (b. 1912)
- May 30 – Doris Hare, English actress, well known for her role in the 1970s comedy, On the Buses (b. 1905)
- May 31 – Tito Puente, American jazz musician (b. 1923)
- July 1 – Walter Matthau, American actor (b. 1920)
- July 7 – James C. Quayle, American newspaper publisher (b. 1921)
- July 8 – FM-2030, Transhumanist philosopher (b. 1930)
- July 10 – Vakkom Majeed, Indian Freedom fighter, Travancore-Cochin Legislative member (b. 1909)
- July 10 – Denis O'Conor Don, hereditary chief of the O'Conor Don sept of Ireland (b. 1912)
- July 11 – Robert Runcie, Archbishop of Canterbury (b. 1921)
- July 12 – Charles Merritt, Canadian Army officer and recipient of the Victoria Cross during World War II (b. 1908)
- July 28 – Abraham Pais, Dutch-born American physicist (b. 1918)
- July 29 – René Favaloro, Argentinian cardiologist who created the technique for coronary bypass surgery (b. 1923)
- August 5 – Sir Alec Guinness, English actor and writer (b. 1914)
- August 5 – Otto Buchsbaum, writer and ecological activist (b. 1920)
- August 6 – Sir Robin Day, British political broadcaster (b. 1923)
- August 9 – John Harsanyi, Hungarian-born economist, Nobel Prize laureate (b. 1920)
- August 12 – Loretta Young, American actress (b. 1913)
- August 12 – Dave Edwards, American musician (b. 1941)
- August 19 – Bineshwar Brahma, Bodo activist and leader (b. 1946)
- August 21 – Daniel Lisulo, Zambian politician (b. 1930)
- August 25 – Carl Barks, American cartoonist (b. 1901)
- August 26 – Bunny Austin, English tennis player (b. 1906)
- September 2 – Elvera Sanchez, American dancer (b. 1905)
- September 2 – Curt Siodmak, American novelist and screenwriter (b. 1902)
- September 14 – Beah Richards, American actress (b. 1920)
- September 16 – Georgiy Gongadze, Ukrainian journalist (b. 1969)
- September 19 – Anthony Robert Klitz, British artist (b 1917)
- September 25 – R. S. Thomas, Welsh poet (b. 1913)
- September 26 – Richard Mulligan, American actor (b. 1932)
- September 27 – Sammy Luftspring, Canadian boxer (b. 1916)
- September 28 – Peter Gennaro, American dancer and choreographer (b. 1919)
- September 28 – Pierre Trudeau, Prime Minister of Canada (b. 1919)
- October 4 – Michael Smith, English-born chemist, Nobel Prize laureate (b. 1932)
- October 6 – Richard Farnsworth, American actor (b. 1920)
- October 8 – Sheila Holland (Sheila Coates, Charlotte Lamb, Sheila Lancaster, Victoria Wolf, Laura Hardy), English writer (b. 1937)
- October 9 – Patrick Anthony Porteous, Scottish recipient of the Victoria Cross (b. 1918)
- October 13 – Jean Peters, American actress (b. 1926)
- October 13 – Tony Roper, NASCAR driver (b. 1964)
- October 15 – Konrad Emil Bloch, German-born biochemist, recipient of the Nobel Prize in Physiology or Medicine (b. 1912)
- October 18 – Julie London, American singer and actress (b. 1926)
- October 21 – Reginald Kray, leading figure in organised crime in London, UK (b. 1933)
- October 23 – Rodney Anoa'i, American wrestler known as Yokozuna (b. 1966)
- October 27 – Walter Berry, Austrian bass-baritone (b. 1929)
- October 29 – Andújar Cedeño, Dominican Major League Baseball player for the Houston Astros (b. 1969)
- October 30 – Steve Allen, American comedian, composer, talk show host, and writer (b. 1921)
- October 31 – Ring Lardner, Jr., American screenwriter, one of the Hollywood Ten (b. 1915)
- November 5 – David Brower, American environmental activist (b. 1912)
- November 5 – Roger Peyrefitte, French writer and diplomat (b. 1907)
- November 6 – L. Sprague de Camp, American writer (b. 1907)
- November 7 – C Subramaniam, Indian politician (b. 1910)
- November 7 – Ingrid of Sweden, Queen consort of Frederick IX of Denmark (b. 1910)
- November 11 – Hugh Paddick, British actor (b. 1915)
- November 22 – Sir Cyril Astley Clarke, British physician, geneticist and entomologist, former President of the Royal College of Physicians (b. 1907)
- November 22 – Christian Marquand, French actor and director (b. 1927)
- December 2 – Gail Fisher, American actress (b. 1935)
- December 3 – Gwendolyn Brooks, African American writer (b. 1917)
- December 10 – Paul Avery, American journalist (b. 1934)
- December 10 – Marie Windsor, American actress (b. 1919)
- December 12 – Gangodawila Soma Thero, Sri Lankan Buddhist Monk (b. 1948)
- December 19 – Roebuck "Pops" Staples, patriarch of The Staple Singers (b. 1914)
- December 23 – Billy Barty, American actor (b. 1924)
- December 23 – Victor Borge, Danish-born comedian and pianist (b. 1909)
- December 26 – Jason Robards, American actor (b. 1922)
- December 30 – Julius J. Epstein, American screenwriter (b. 1909)